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Age-Associated Dysregulation of Protein Metabolism in the Mammalian Oocyte

Duncan, Francesca E.; Jasti, Susmita; Paulson, Ariel; Kelsh, John M.; Fegley, Barbara; Gerton, Jennifer L.

Obstetrical & Gynecological Survey: October 2018 - Volume 73 - Issue 10 - p 580
doi: 10.1097/01.ogx.0000547166.00110.c6
GYNECOLOGY: GENETICS

(Abstracted from Aging Cell 2017;16:1381–1393)

The growing oocyte is one of the most translationally active cells in the body and must accumulate high-quality, maternally derived proteins to support subsequent embryo development. Women of advanced reproductive age are at increased risk of infertility, miscarriages, and birth defects because of a marked decline in oocyte quality.

Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS (F.E.D., S.J., J.M.K., B.F.); Stowers Institute for Medical Research, Kansas City, MO (A.P., J.L.G.); and Electron Microscopy Research Laboratory (B.F.) and Department of Biochemistry and Molecular Biology (J.L.G.), University of Kansas Medical Center, Kansas City, KS

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