(Abstracted from Aging Cell 2017;16:1381–1393)
The growing oocyte is one of the most translationally active cells in the body and must accumulate high-quality, maternally derived proteins to support subsequent embryo development. Women of advanced reproductive age are at increased risk of infertility, miscarriages, and birth defects because of a marked decline in oocyte quality.
Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS (F.E.D., S.J., J.M.K., B.F.); Stowers Institute for Medical Research, Kansas City, MO (A.P., J.L.G.); and Electron Microscopy Research Laboratory (B.F.) and Department of Biochemistry and Molecular Biology (J.L.G.), University of Kansas Medical Center, Kansas City, KS