(Abstracted from Ultrasound Obstet Gynecol 2018;51:194–198)
Major congenital heart defects (CHDs) are those that require invasive interventions within the first year following birth and are often associated with fetal growth restriction (FGR). A recent study on isolated major CHDs found evidence of impaired placental angiogenesis in the absence of impaired placental perfusion and function in pregnancies with fetal CHD.
Harris Birthright Research Centre for Fetal Medicine, King’s College Hospital, London (I.F., D.K., T.K., A.S., R.A., K.H.N.); and Department of Fetal Medicine, Medway Maritime Hospital, Gillingham (R.A.), United Kingdom