(Abstracted from Diabetologia 2017;60:1612–1619)
Metformin has been prescribed in pregnancy for more than 40 years, but it is since its increased use in polycystic ovarian syndrome treatment that exposure of the fetus to metformin in early pregnancy and its safety for both mother and child have been investigated more robustly. This review discusses the history, key trials, and controversies associated with metformin use in pregnancy.
Institute of Cardiovascular and Medical Sciences, British Heart Foundation, Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom (R.S.L.); and Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, MA (M.R.L.)