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LINE-1 Activation After Fertilization Regulates Global Chromatin Accessibility in the Early Mouse Embryo

Jachowicz, Joanna, W.; Bing, Xinyang; Pontabry, Julien; Bošković, Ana; Rando, Oliver, J.; Torres-Padilla, Maria-Elena

Obstetrical & Gynecological Survey: February 2018 - Volume 73 - Issue 2 - p 97–98
doi: 10.1097/OGX.0000000000000534
GYNECOLOGY: GENETICS
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(Abstracted from Nat Genet 2017;49:1502–1510)

After fertilization, gametes undergo dramatic epigenomic reprogramming to initiate embryonic development. Retrotransposons are repetitive elements that form almost half of the mammalian genome; some are transcribed after fertilization.

Institute of Epigenetics and Stem Cells, Helmholtz Zentrum München, München, Germany (J.W.J., J.P., M.-E.T.-P.); INSERM U964, U de S, CU de Strasbourg, Illkirch, France (J.W.J., M.-E.T.-P.); and Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA (X.B., A.B., O.J.R.)

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