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Effect of Post–Cesarean Delivery Oral Cephalexin and Metronidazole on Surgical Site Infection Among Obese Women

A Randomized Clinical Trial

Valent, Amy M.; DeArmond, Chris; Houston, Judy M.; Reddy, Srinidhi; Masters, Heather R.; Gold, Alison; Boldt, Michael; DeFranco, Emily; Evans, Arthur T.; Warshak, Carri R.

Obstetrical & Gynecological Survey: February 2018 - Volume 73 - Issue 2 - p 85–87
doi: 10.1097/01.ogx.0000530381.99105.a9

(Abstracted from JAMA 2017;318(11):1026–1034)

Surgical site infection (SSI) is a major complication of cesarean delivery, and the risk of SSI increases with obesity despite recommended preoperative antibiotic regimens. This randomized clinical trial aimed to compare the efficacy of postoperative, prophylactic oral cephalexin plus metronidazole with standard preoperative intravenous cephalosporin alone on SSI among obese women after cesarean delivery.

Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR (A.M.V.); Department of Obstetrics and Gynecology, University of Cincinnati (C.D., H.R.M., M.B., E.D., A.T.E., C.R.W.), and Office of Clinical Research, Investigational Pharmacy, University of Cincinnati Health (J.M.H.), Cincinnati, OH; Department of Obstetrics and Gynecology, University of Texas Health Science Center, San Antonio, TX (S.R.); and Miami Ob/Gyn LLC, Miami, FL (A.G.)

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