(Abstracted from N Engl J Med 2017;377:613–622)
Since 1979, multiple studies have shown that low-dose aspirin in pregnancy can lower the occurrence of preeclampsia. Subsequent studies have shown that doses greater than 100 mg/d started before 16 weeks of gestation are most effective.
King’s College Hospital (D.L.R., L.C.P., N.O., A.S., R.A., K.H.N.), Homerton University Hospital (S.C.), North Middlesex University Hospital (D.J.), and University College London Comprehensive Clinical Trials Unit (K.M.), London; University of Exeter, Exeter (D.W.); Medway Maritime Hospital, Gillingham (R.A.); Southend University Hospital, Westcliff-on-Sea (M.S.), United Kingdom; Chinese University of Hong Kong, Hong Kong (L.C.P.); Hospital Clínico Universitario Virgen de la Arrixaca, Murcia (C.P.M.); Hospital Universitario San Cecilio, Granada (F.S.M.); Hospiten Group, Tenerife (W.P.), Spain; Ospedale Maggiore Policlinico, Milan, Italy (N.P.); University Hospital Brugmann, Université Libre de Bruxelles, Brussels, Belgium (J.C.J.); Attikon University Hospital, Athens, Greece (G.P.); Rabin Medical Center, Petach Tikva (K.T.-G.); HyLabs Diagnostics, Rehovot (H.M.), Israel; and University of Iceland, Reykjavik, Iceland (S.G.)
