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Meta-analysis of Randomized Controlled Trials Comparing 17α-Hydroxyprogesterone Caproate and Vaginal Progesterone for the Prevention of Recurrent Spontaneous Preterm Delivery

Oler, Elizabeth; Eke, Ahizechukwu C.; Hesson, Ashley

Obstetrical & Gynecological Survey: December 2017 - Volume 72 - Issue 12 - p 692–694
doi: 10.1097/01.ogx.0000527933.35057.e1
OBSTETRICS: PRECONCEPTION AND PRENATAL CARE
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(Abstracted from Int J Gynecol Obstet 2017;138:12–16)

Although the incidence of preterm delivery is decreasing in the United States, it is a leading cause of long-term disability, in addition to contributing to maternal adverse events and neonatal morbidity and mortality. The decreasing incidence of preterm delivery is thought to be due in part to the use of progesterone therapy, including vaginal progesterone and intramuscular 17α-hydroxyprogesterone acetate (17α-OHP).

Department of Obstetrics and Gynecology (E.O.) and Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology (A.C.E.), Johns Hopkins University School of Medicine, Baltimore, MD; and Department of Obstetrics and Gynecology, University of Michigan School of Medicine, Ann Arbor, MI (A.H.)

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