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Plasma Leptin and Premenstrual Syndrome: A Review

Nicolau, Zaira Fernanda Martinho MD*; Bezerra, Andréia Gomes MSc; Polesel, Daniel Ninello PhD; Andersen, Monica Levy PhD§; Tufik, Sergio MD, PhD; Hachul, Helena MD, PhD∥**

Obstetrical & Gynecological Survey: November 2017 - Volume 72 - Issue 11 - p 659–662
doi: 10.1097/OGX.0000000000000502

Importance Premenstrual syndrome (PMS) is characterized by physical and psychological symptoms in the luteal phase. Leptin can influence PMS as it acts on the hypothalamic-pituitary-gonadal axis.

Objective The aim of this study was to evaluate data in the literature about the profile of plasma leptin in women with PMS.

Evidence Acquisition We performed a search of databases using both descriptors. Three studies were identified. They included 181 participants. Two of these studies found higher leptin levels in women with PMS.

Results Conflicting results were found regarding the leptin levels in the luteal phase and the correlation between leptin, estradiol, and progesterone levels.

Conclusions and Relevance Leptin could have a role in the pathophysiology of PMS and indicate degree of severity of PMS. Future studies on the role of leptin in PMS are needed.

Target Audience Obstetricians and gynecologists, family physicians.

Learning Objectives After completing this activity, the learner should be better able to describe the correlation between women with PMS and leptin concentration, analyze if there is a difference between leptin concentration in the phases of the menstrual cycle, and foresee the future clinical applicability of leptin's concentration in women with PMS.

*Research Assistant; †Biomedical Researcher, ‡Research Associate, §Associate Professor, and ¶Full Professor, Department of Psychobiology; ∥Head of Women's Sleep Medicine Division, Departments of Psychobiology and Gynecology, Universidade Federal de São Paulo; and **Department of Gynecology, Casa de Saúde Santa Marcelina, São Paulo, Brazil

All authors, faculty, and staff in a position to control the content of this CME activity and their spouses/life partners (if any) have disclosed that they have no financial relationships with, or financial interests in, any commercial organizations pertaining to this educational activity.

Correspondence requests to: Helena Hachul, MD, PhD, Rua Napoleao de Barros, 925, São Paulo, São Paulo, Brazil CEP 04021-002. E-mail:

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