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Risk of Cervical Intra-epithelial Neoplasia and Invasive Cancer of the Cervix in DES Daughters

Verloop, J.; van Leeuwen, F. E.; Helmerhorst, Th. J. M.; de Kok, I. M. C. M.; van Erp, E. J. M.; van Boven, H. H.; Rookus, M. A.

Obstetrical & Gynecological Survey: October 2017 - Volume 72 - Issue 10 - p 596–598
doi: 10.1097/OGX.0000000000000484
GYNECOLOGY: GYNECOLOGIC ONCOLOGY
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(Abstracted from Gynecol Oncol 2017;144:305–311)

Several million pregnant women worldwide received diethylstilbestrol (DES) from the late 1940s to the early 1970s to prevent miscarriages and other pregnancy complications. Women exposed to DES in utero have an increased risk of clear cell adenocarcinoma (CCA) of the vagina and cervix; their risk of non–CCA-invasive cervical cancer remains unclear.

Department of Epidemiology, Netherlands Cancer Institute, Amsterdam (J.V., F.E.v.L., M.A.R.); Department of Obstetrics and Gynaecology, Erasmus MC, University Hospital Rotterdam (Th.J.M.H.); Department of Public Health, Erasmus MC (I.M.C.M.d.K.); De Praktijk, Utrecht (E.J.M.v.E.); and Department of Pathology, Netherlands Cancer Institute, Amsterdam (H.H.v.B.), the Netherlands

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