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Chromosomal Polymorphisms Are Associated With Female Infertility and Adverse Reproductive Outcomes After Infertility Treatment: A 7-Year Retrospective Study

Cheng, Ran; Ma, Yaxian; Nie, Ying; Qiao, Xiaoyong; Yang, Zhilan; Zeng, Rujun; Xu, Liangzhi

Obstetrical & Gynecological Survey: October 2017 - Volume 72 - Issue 10 - p 600–601
doi: 10.1097/OGX.0000000000000495
GYNECOLOGY: GENETICS
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(Abstracted from Reprod Biomed Online 2017;35:72–80)

It was believed for a long time that chromosomal polymorphisms—most of which have no effect on phenotypes—had no clinical significance. However, a large number of studies have shown that chromosomal polymorphisms are associated with an increased frequency of polymorphic variations in infertile patients.

Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University; The Joint Laboratory for Reproductive Medicine of Sichuan University, The Chinese University of Hong Kong; and Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China

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