(Abstracted from JAMA 2017;317(15):1553–1562)
While antidepressant use during pregnancy has been associated with adverse birth and neurodevelopmental outcomes, these associations may be attributed to confounding factors, such as genetic influences, maternal stress, or poor health practices during pregnancy. This study used 4 observational designs to investigate these associations, including sibling and paternal information.
Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN (A.C.S., M.E.R., P.D.Q., B.M.D.); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (A.S.Ö., C.A., P.L., H.L., B.M.D.); Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (A.S.Ö., S.H.-D.); and School of Medical Sciences, Örebro University, Örebro, Sweden (H.L.)