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Associations of Maternal Antidepressant Use During the First Trimester of Pregnancy With Preterm Birth, Small for Gestational Age, Autism Spectrum Disorder, and Attention-Deficit/Hyperactivity Disorder in Offspring

Sujan, Ayesha C.; Rickert, Martin E.; Öberg, A. Sara; Quinn, Patrick D.; Hernández-Díaz, Sonia; Almqvist, Catarina; Lichtenstein, Paul; Larsson, Henrik; D'Onofrio, Brian M.

Obstetrical & Gynecological Survey: September 2017 - Volume 72 - Issue 9 - p 523–524
doi: 10.1097/01.ogx.0000524510.66825.09
OBSTETRICS: MEDICAL COMPLICATIONS OF PREGNANCY
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(Abstracted from JAMA 2017;317(15):1553–1562)

While antidepressant use during pregnancy has been associated with adverse birth and neurodevelopmental outcomes, these associations may be attributed to confounding factors, such as genetic influences, maternal stress, or poor health practices during pregnancy. This study used 4 observational designs to investigate these associations, including sibling and paternal information.

Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN (A.C.S., M.E.R., P.D.Q., B.M.D.); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (A.S.Ö., C.A., P.L., H.L., B.M.D.); Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (A.S.Ö., S.H.-D.); and School of Medical Sciences, Örebro University, Örebro, Sweden (H.L.)

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