(Abstracted from Proc Natl Acad Sci U S A 2017;114:3186–3191)
The ovaries have a fixed pool of immature (primordial) follicles at birth known as the ovarian reserve. Activation or loss of follicles in this reserve causes an irreversible decline in reproductive function that culminates in menopause.
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology (K.N.G., D.L.K., J.A.G.), and Department of Microbiology (D.C., R.A., R.J.S.), New York University School of Medicine, New York, NY; Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL (F.E.D.); and Perlmutter Cancer Center, New York University School of Medicine, New York, NY (R.J.S.)