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Anti–Müllerian Hormone Levels in Chinese Women Younger Than 30 Years and 30 Years or Older and Correlated Biochemical Indices

Zhu, Jieping PhD; Wang, Jun MS; Chen, Yu MS; Ji, Yuqin MS; Xiong, Miao MS

Obstetrical & Gynecological Survey: January 2017 - Volume 72 - Issue 1 - p 33–38
doi: 10.1097/OGX.0000000000000389
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CME

Importance Anti–müllerian hormone (AMH) is considered an important marker of ovarian reserve; however, the exact function of AMH has yet to be determined.

Objective Our purpose was to investigate factors correlated with AMH levels in Chinese women.

Evidence Acquisition Healthy women were divided into 2 groups: aged younger than 30 years and 30 years or older. Anti–müllerian hormone levels and biochemical indices were compared between the groups.

Results Eighty women younger than 30 and 29 women 30 years or older were included. The mean AMH level in women younger than 30 years was 8.2 ± 4.4 ng/mL (range, 0.1–17.2 ng/mL), and in those 30 years or older was 5.2 ± 4.3 ng/mL (range, 0.1–13.3 ng/mL). Half of women younger than 30 years had an AMH level above a median of 8.0 ng/mL (interquartile range, 4.9–11.2 ng/mL), whereas the median in those 30 years or older was 4.6 ng/mL (interquartile range, 1.3–8.5 ng/mL). In women younger than 30 years, calcium was positively correlated (P = 0.014) and sex hormone–binding globulin (SHBG) was negatively correlated with AMH (P < 0.001). No correlations of calcium and SHBG with AMH were found in women 30 years or older, but a positive correlation between triglycerides and testosterone and AMH was noted (P = 0.020 and P = 0.007, respectively).

Conclusions and Relevance Anti–müllerian hormone levels are positively or negatively correlated with testosterone, calcium, SHBG, and triglycerides in Chinese women.

Target Audience Obstetricians and gynecologists, family physicians.

Learning Objectives After completing this activity, the learner should be better able to investigate the factors that affect AMH level in Chinese women, the relation of age and AMH level in Chinese women, and the correlations between AMH level and other biochemical indices.

*Executive Director, †Associate Senior Doctor, and ‡Attending Doctor, Department of Obstetrics and Gynecology, Shanghai 6th People's Hospital, Shanghai, China

All authors and staff in a position to control the content of this CME activity and their spouses/life partners (if any) have disclosed that they have no financial relationships with, or financial interests in, any commercial organizations pertaining to this educational activity.

Correspondence requests to: Jieping Zhu, PhD, Department of Obstetrics and Gynecology, Shanghai 6th People's Hospital, No. 222, Huanhu West 3 Rd, Nanhui New City, Pudong New Area, Shanghai 201306, China. E-mail: pinger_1225@sina.com.

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