Active immunization during pregnancy for maternal and neonatal benefit is a remarkably promising strategy to reduce infectious morbidity in both women and infants. The aim of this review is to present current clinical guidelines for vaccination during pregnancy and review evidence-based strategies for the implementation of maternal immunization recommendations. Observational studies, clinical trials, cost-effectiveness analyses, systematic reviews, and meta-analyses were evaluated to generate the evidence base for this review. In addition, recommendations from major national professional and public health organizations were examined. We present current clinical recommendations for vaccination during pregnancy and review medical and public health strategies to implement these guidelines. We also discuss a research agenda to advance the field of maternal immunization and achieve further improvements in maternal and child health.
Obstetricians, gynecologists, and family physicians
After completing this activity, the learner should be better able to discuss the importance of vaccination during pregnancy for both maternal and neonatal benefit; explain the physiologic basis for maternal vaccination; understand the most effective ways to enhance uptake of recommended vaccines during pregnancy; and appreciate the ongoing and future research in this area.