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A Comprehensive Review of Diagnostic and Treatment Options for Granulosa Cell Tumors of the Ovary

Stine, Jessica E. MD*; Pierce, Stuart MD; Soper, John T. MD

Obstetrical & Gynecological Survey: January 2014 - Volume 69 - Issue 1 - p 29–38
doi: 10.1097/OGX.0000000000000010

Granulosa cell tumors are rare and comprise approximately 2% to 8% of all ovarian malignancies. Research dedicated to these tumors is rare given the low incidence. These tumors are more difficult to diagnose than epithelial ovarian tumors, and understanding how they present may aid in appropriate referral to a gynecologic oncologist. The aim of this review was to summarize the epidemiology, risk factors, and clinical presentation of granulosa cell tumors to aid in provider recognition. We will also explore current diagnostic and treatment modalities with examination of newer, novel treatments. At the end of this review, the reader should understand how to appropriately diagnose and treat these rare malignancies.

Target Audience Obstetricians and gynecologists, family physicians

Learning Objectives After completing this CME activity, physicians should be better able to summarize the epidemiology, risk factors, and clinical presentation of granulosa cell tumors of the ovary, identify current diagnostic modalities to aid in provider recognition, and apply treatment options including examination of newer, novel treatments, to care for patients.

*Fellow Gynecologic Oncology, †Resident Obstetrics and Gynecology, and ‡Professor Gynecologic Oncology, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC

All authors and staff in a position to control the content of this CME activity and their spouses/life partners (if any) have disclosed that they have no financial relationships with, or financial interests in, any commercial organizations pertaining to this educational activity.

Correspondence requests to: Jessica E. Stine, MD, Lineberger Comprehensive Cancer Center, Obstetrics and Gynecology, Campus Box 7572, Chapel Hill, NC. E-mail:

© 2014 by Lippincott Williams & Wilkins.