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Ehlers-Danlos Syndrome: Insights on Obstetric Aspects

Volkov, Natalie MD*; Nisenblat, Victoria MD*; Ohel, Gonen MD; Gonen, Ron MD

Obstetrical & Gynecological Survey: January 2007 - Volume 62 - Issue 1 - p 51-57
doi: 10.1097/01.ogx.0000251027.32142.63

Ehlers-Danlos syndrome (EDS) is a heterogeneous group of connective tissue disorders characterized by joint hypermobility, skin hyperelasticity, tissue fragility, easy bruising, and poor healing of wounds. The clinical manifestations vary depending on the type of disease. The syndrome may be associated with a number of pregnancy and peripartum complications. Because of the multi-organ involvement and varied presentation of this disease, no uniform or routine obstetric and anesthetic recommendations can be made for the perinatal care of these patients. We present a review of the literature on EDS with emphasis on the obstetric, anesthetic, and perinatal consequences. We also report our experience with this syndrome: an uneventful term vaginal delivery in a 32-year-old woman diagnosed with hypermobility type of EDS.

Target Audience: Obstetricians & Gynecologists, Family Physicians

Learning Objectives: After completion of this article, the reader should be able to recall the potentially severe nature of Ehlers-Danlos Syndrome (EDS) in both pregnant and nonpregnant patients, summarize the wide range of signs and symptoms and its genetic inheritance, and explain the difficulty in recommending obstetric and anesthesia procedures to avoid complications.

*Resident, Department of Obstetrics and Gynecology, Bnai Zion Medical Center, Haifa, Israel; †Chairman and ‡Deputy Chairman, Director of Maternal and Fetal Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine, Technion–Israel Institute of Technology, Haifa, Israel

Chief Editor's Note: This article is part of a series of continuing education activities in this Journal through which a total of 36 AMA/PRA Category 1 Credits™ can be earned in 2007. Instructions for how CME credits can be earned appear on the last page of the Table of Contents.

The authors have disclosed that they have no financial relationships with or interests in any commercial companies pertaining to this educational activity.

Lippincott Continuing Medical Education Institute, Inc. has identified and resolved all faculty conflicts of interest regarding this educational activity.

Reprints will not be available.

Address correspondence to: Ron Gonen, MD, Deputy Chairman, Department of Obstetrics and Gynecology, Director of Maternal-Fetal Medicine, Bnai Zion Medical Center, 47 Golomb Street, Haifa 31048, Israel. E-mail:

© 2007 Lippincott Williams & Wilkins, Inc.