Clinical Issues Surrounding The Use Of Terbutaline Sulfate For Preterm LaborClinical Issues Surrounding the Use of Terbutaline Sulfate for Preterm LaborLam, Fung; Elliott, John; Jones, J. Stephen; Katz, Michael; Knuppel, Robert A.; Morrison, John; Newman, Roger; Phelan, Jeffrey; Willcourt, RobinAuthor Information California-Pacific Medical Center, San Francisco, California; Good Samaritan Regional Medical Center, Phoenix, Arizona; Carolina Perinatal Obstetrics, Greenville, South Carolina; University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey; University of Mississippi, Jackson, Mississippi; Medical University of South Carolina, Charleston, South Carolina; Pomona Valley Medical Center, Pomona, California; and Northern Nevada Medical Center, Reno, Nevada Reprint requests to: Fung Lam, MD, California Perinatal, 3838 California Street, Suite 812, San Francisco, CA 94118. Obstetrical & Gynecological Survey: November 1998 - Volume 53 - Issue 11S - p 85S-95S Buy Abstract Beta-mimetics have been prescribed by physicians to arrest or prevent premature labor for more than 20 years. Although not approved by the Food and Drug Administration (FDA) for tocolytic use, terbutaline sulfate has been the most widely prescribed beta-mimetic in the United States. Recently, the role of terbutaline in the treatment and prevention of preterm labor has been questioned by the FDA. Because the off-label use of drugs is a formally accepted practice in medicine when scientific studies support such use, we reviewed the currently available clinical literature on terbutaline use in various routes of delivery: intravenous, oral, and subcutaneous via infusion pump. This review describes the clinical evidence that supports the safe and effective use of terbutaline as a tocolytic agent in certain patient populations. Practicing physicians should continue to have unrestricted use of terbutaline for tocolysis as one of the few remaining therapeutic options remaining in the fight against preterm birth. © Williams & Wilkins 1998. All Rights Reserved.