review: PDF OnlyDevelopment of Cervical and Vaginal Squamous Cell Neoplasia As a Late Consequence ofIn UteroExposure to DiethylstilbestrolBORNSTEIN, JACOB1; ADAM, ERVIN1,2; ADLER-STORTHZ, KAREN3; KAUFMAN, RAYMOND H.1Author Information 1Department of Obstetrics and Gynecology and Department of2Virology and Epidemiology, Baylor College of Medicine, Houston; and Department of3Microbiology, University of Texas Dental Branch, Houston, Texas Reprint requests to: Raymond H. Kaufman, M.D., Department of OB/GYN, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030. Obstetrical & Gynecological Survey: January 1988 - Volume 43 - Issue 1 - p 15-21 Buy Abstract During the last 14 years, several articles have given contradictory reports on prevalence rates of squamous cell neoplasia of the cervix and vagina in diethylstilbestrol (DES)-exposed progeny. In 1984, the DES-Adenosis (DESAD) Project found that the incidence of cervical and vaginal intraepithelial neoplasia in DES-exposed daughters was twice as high as in a comparison group of unexposed women. This was also associated with a higher rate of herpes simplex virus and human papillomavirus infections. Possible hypotheses on the etiology of the increased incidence of squamous neoplasia are discussed. © Williams & Wilkins 1988. All Rights Reserved.