Secondary Logo

Journal Logo

Institutional members access full text with Ovid®

Polymorphisms in Genes Coding for Folate-Related Enzymes and Colorectal Cancer

Gholamalizadeh, Maryam MSc; Doaei, Saeid PhD; Shahvegharasl, Zahra MSc; Hajiesmaeil, Mogge MSc; Aminifard, Atefeh MSc; Mosavi-Jarrahi, Alireza PhD; Mohammad, Esmail Akbari MD; Mirzaei Dahka, Samaneh BSc

doi: 10.1097/NT.0000000000000365
Clinical Nutrition
Buy

This review examined the association between folate and risk of colorectal cancer and single-nucleotide polymorphisms in 4 genes coding for folate metabolism–related enzymes may be involved. Individuals with single-nucleotide polymorphisms in these key enzymes in the folate pathways may need different amounts of dietary folate to prevent colorectal cancer.

Maryam Gholamalizadeh, MSc, is a PhD candidate of clinical nutrition and works on the associations between colon cancer and nutrition Student Research Committee, Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Saeid Doaei, PhD, is a postdoctoral fellow on nutrition and cancer in the Research Centre of Health and Environment, Guilan University of Medical Sciences, Rasht, Iran.

Zahra Shahvegharasl, MSc, is a researcher interested in nutritional epidemiology in the Faculty of Nutrition Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.

Mogge Hajiesmaeil, MSc, is a researcher on genetics in the Department of Biology, Parand Branch, Islamic Azad University, Parand, Iran.

Atefeh Aminifard, MSc, is a researcher on nutritional sciences in the Food Sciences and Industry, Khouzestan Sciences and Research Branch, Islamic Azad University, Khouzestan, Iran.

Alireza Mosavi-Jarrahi, PhD, is the president of Asia Pacific Organization for Cancer Prevention and Faculty of Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Mohammad Esmail Akbari, MD, is professor in the Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Samaneh Mirzaei Dahka, BSc, is an MSc student of nursing interested in nutritional genomics, Student Research Committee, School of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, Iran.

This study was funded by student research committee of Shahid Beheshti University of Medical Sciences (code 1397/3903).

The authors have no conflicts of interest.

The authors contributed equally to this work.

Correspondence: Saeid Doaei, The Research Centre of Health and Environment, Guilan University of Medical Sciences, Rasht, Iran (rmosavi@yahoo.com).

Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.