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Exploring the Soyfood Controversy

Messina, Mark PhD, MS; Messina, Virginia L. MPH, RD

doi: 10.1097/NT.0b013e31828fff54
Food and Nutrition

Despite their proposed health benefits and long history of consumption in Asia, soyfoods have become controversial. In recent years, the benefits of soy have been challenged, and concerns have been raised about possible adverse effects of soy consumption. Underlying most of the benefits and concerns is the presence of isoflavones (phytoestrogens) in soybeans. The evidence reviewed in this article indicates that soy consumption reduces risk of coronary heart disease and, if consumed early in life, potentially breast cancer. Concerns that soyfoods may be contraindicated for breast cancer patients and women at high risk of developing this disease are not supported by the clinical and epidemiologic evidence. The clinical evidence also does not support the notion that isoflavones or soyfoods feminize men. However, some question remains as to their effects in subclinical hypothyroid patients, although soyfoods do not adversely affect thyroid function in healthy subjects. The preponderance of the evidence indicates that for healthy individuals, with the exception of those relatively rare persons with allergies to soy protein, soyfoods can make important contributions to the diet.

A look into a soy-based diet

Mark Messina, PhD, MS, is an adjunct associate professor at the Department of Nutrition School of Public Health, Loma Linda University, California and president of Nutrition Matters, Inc, and has focused on the health effects of soyfoods for more than 20 years.

Virginia L. Messina, MPH, RD, is an adjunct assistant professor at the Department of Nutrition School of Public Health, Loma Linda University, California, and vice president of Nutrition Matters, Inc, Port Townsend, Washington, and is a consulting nutritionist specializing in vegetarian nutrition.

Dr. Messina regularly consults for companies that manufacture and/or sell soyfoods and/or soy isoflavone supplements. Ms. Messina has no conflicts of interest to disclose.

Correspondence: Mark Messina, PhD, MS, Department of Nutrition School of Public Health, Loma Linda University and Nutrition Matters, Inc, 439 Calhoun St, Port Townsend, WA 98368 (

© 2013 Lippincott Williams & Wilkins, Inc.