Stress and Health in Nursing Students: The Nurse Engagement and Wellness Study : Nursing Research

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Stress and Health in Nursing Students

The Nurse Engagement and Wellness Study

Olvera Alvarez, Hector A.; Provencio-Vasquez, Elias; Slavich, George M.; Laurent, Jose Guillermo Cedeño; Browning, Matthew; McKee-Lopez, Gloria; Robbins, Leslie; Spengler, John D.

Author Information
Nursing Research 68(6):p 453-463, 11/12 2019. | DOI: 10.1097/NNR.0000000000000383


As the largest group of healthcare professionals in the world, nurses play a far-reaching role in healthcare systems. In hospitals, direct patient contact places nurses in a position to directly affect the outcomes, safety, and satisfaction of patients. However, chronic psychosocial stress can negatively affect the capacity of nurses to provide quality care by increasing risk for medical error (Elfering, Semmer, & Grebner, 2006) and reducing job satisfaction (Roberts & Grubb, 2014). Nurses experience stress as a result of demanding work responsibilities, long shifts, frequently changing roles (Moustaka & Constantinidis, 2010), and—in some instances—incivility between coworkers (Oyeleye, Hanson, O’Connor, & Dunn, 2013). This type of frequent and prolonged stress exposure can cause biological deterioration (i.e., allostatic load) that increases individuals’ susceptibility to numerous health problems and cognitive decline (McEwen, 1998).

Among nurses, work-related stress has been associated with health problems such as obesity, cardiovascular disease, and Type 2 diabetes (McNeely, 2005), as well as with greater risk for depression, burnout, and suicidality (Karasek & Theorell, 1990). Chronic stress can also affect cognitive function, including attention and memory, which among nurses could increase their risk of committing medication errors, failing to recognize life-threatening signs and symptoms, or missing other critical patient safety issues (Karimi, Adel-Mehraban, & Moeini, 2018; McEwen, 1998). Stress also increases turnover (i.e., quitting current job) and attrition (i.e., quitting nursing) (Hayes et al., 2012; Shader, Broome, Broome, West, & Nash, 2001), particularly among new nurses (Blythe et al., 2008; Rudman, Omne-Ponten, Wallin, & Gustavsson, 2010), which in turn reduces the effectiveness and productivity of understaffed nursing teams (Newman, Maylor, & Chansarkar, 2001; Squillace, Bercovitz, Rosenoff, & Remsburg, 2008).

New nurses appear to be particularly vulnerable to stress during their transition from nursing school to the work environment (Fink, Krugman, Casey, & Goode, 2008). During the first 2 years after graduation, 34% of nurses change jobs, with stress being among the more frequent reasons for leaving (Kovner, Brewer, Fatehi, & Jun, 2014; Kovner & Djukic, 2009). Studies have also reported that professions that require continuous human contact, such as nursing, are susceptible to stress and burnout even before employment (Moreira & Furegato, 2013; Rudman & Gustavsson, 2012). Nursing students, for example, encounter stressors unique to the nursing curriculum, such as clinical training (Pulido-Martos, Augusto-Landa, & Lopez-Zafra, 2012), and experience more stress from experiences common to other college students, such as test anxiety (Turner & McCarthy, 2017). The need to balance financial, family, and other life issues, along with academic demands, can also lead to severe stress among students. At this time, however, little is known about how stress experienced in nursing school is associated with susceptibility to stress in the work environment. A better understanding of how students experience stress could improve the performance and well-being of new nurses and, ultimately, the health of their patients.

The effect that stress has on the health and performance of nursing students can be mediated by other life stressors, as well as personal, behavioral, social, and environmental factors that are experienced during school or earlier in life. For instance, the type, number, and severity of stressors experienced during childhood appears to increase the sensitivity and inflammatory response to stress experienced later in life (Nusslock & Miller, 2016), which can in turn elevate risk for depression, cardiovascular disease, and hypersensitivity to chemicals and air pollutants (Bell, Baldwin, Russek, Schwartz, & Hardin, 1998; Black, Okiishi, Gabel, & Schlosser, 1999; Olvera Alvarez, Kubzansky, Campen, & Slavich, 2018). Personality might also modify the stress experience of nursing students (Aldwin, Spiro, Levenson, & Cupertino, 2001; Judge & Ilies, 2002). Behaviors such as sleep, diet, and physical activity lessen or amplify the effect of stress on health as a result of inflammation in the body (Cecil, McHale, Hart, & Laidlaw, 2014; Gleeson et al., 2011; Minihane et al., 2015). The amount and type of social support (Thoits, 2011) and attachment (Mattanah, Lopez, & Govern, 2011) have also been associated with protective health outcomes. Although research on stress among nurses and nursing students is abundant, no studies have examined how behavioral, social, and environmental factors interact in nursing students. This has occurred despite the fact that comprehensive assessments of how these multilevel and multidimensional factors interact could help us prepare the next generation of nurses to thrive and deliver high-quality care in often-challenging work environments.

The Nurse Engagement and Wellness Study (NEWS) addresses these important issues by examining how behavioral, social, and environmental factors interact to modify the effects of stress on the health and performance of nursing students. NEWS also seeks to investigate how the stress experience in nursing school transcends into the professional work environment. In this first article on NEWS, we provide an overview of the study design and describe key associations between stress and health-related characteristics in the cohort at baseline.


Study Design

The NEWS is a prospective cohort study of nursing students and early career nurses directed by a team of nursing, social, and environmental health researchers. Data and biological samples are stored at the Biobehavioral Research Laboratory at University of Texas at El Paso. The study was approved by institutional review boards at University of Texas at El Paso (857149-1) and Harvard University (16-0080).


Female and male individuals between 18 and 55 years old, enrolled in the bachelor of science in nursing (BSN) program at the University of Texas at El Paso, were eligible to participate. Participants were recruited via e-mails, posters, flyers, media outlets (e.g., magazine, newsletter), and in-class information sessions. No member of the research team was an instructor in the BSN program during the study. Interested students were asked to visit the laboratory where they provided written informed consent. Participants who dropped out of the BSN program, transferred to another university, or failed to graduate from the program were removed from the sample.

Data Collection

Data were collected at three time points. Baseline measurements were conducted within 6 months of students entering the BSN program. The first follow-up was within 4 months prior to graduation from the BSN program. Finally, the second follow-up was within 12–24 months after graduation (Figure 1).

Schematic of the study design of Nurse Engagement and Wellness Study. Baseline assessments were conducted during their first 6 months in the bachelor of science in nursing program, the first follow-up was conducted 4 months prior to graduation, and the second follow-up was conducted 1 year after graduation. CM = clinical measures; BS = biological sampling; SA = self-assessments.

Study assessments included health endpoints, biomarkers, life stress exposure, behaviors and personal traits, social factors, indicators of engagement and performance, and environmental exposures, which were conducted via clinical measures, biological samples, and self-reports as described in Supplemental Digital Content 1, Clinical measures and biological samples were collected during laboratory visits. Serum and plasma were separated from blood samples by centrifugation within an hour of collection. Saliva was collected using the passive drool technique (Salimetrics, 2015). Stool samples were collected by participants using two Para-Pak vials: one containing 5 ml of RNAlater preservative and another containing 10 ml of glycerol solution and 2 ml of acid-washed glass beads. Participants placed a small, teaspoon-sized sample in each tube, stored the samples in their freezer in a designated package, and delivered the sample to the laboratory within 24 hours. Then, serum, plasma, saliva, and stool samples were stored at −80°C until analysis.

During each time point, participants also completed the list of self-assessments described in Supplemental Digital Content 1, Participants had 12 weeks, starting at the beginning of the academic semester, to complete these instruments. They were required to complete each assessment once enrolled in the cohort. The date and time of completion of each assessment were recorded.

Study Assessments

Health Endpoints and Biomarkers

Indicators of metabolic health included systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), and fasting levels of triglycerides, cholesterol (total, low-density lipoprotein [LDL], high-density lipoprotein [HDL]), glucose, and glycohemoglobin (A1c). Cardiovascular endpoints included carotid intima-media thickness (CIMT) measured via ultrasound (Stein et al., 2008), heart rate variability measured via electrocardiogram, and retinal blood vessel caliber measured via fundus imaging (De Boever, Louwies, Provost, Int Panis, & Nawrot, 2014). Retinal arterial narrowing has been shown to predict hypertension, and venular widening has been linked with systemic inflammation, endothelial dysfunction, and atherosclerosis (Adar et al., 2010; Louwies, Panis, Kicinski, De Boever, & Nawrot, 2013). Depressive severity was measured with the patient health questionnaire for depression (Patient Health Questionnaire-9). Symptoms of chemical sensitivity such as skin and eye irritation, dizziness, pain, fatigue, stomachache, asthma and allergies diagnosis, headache, and balance problems were assessed using a modified survey version of an existing environmental sensitivities survey (Andersson, Andersson, Bende, Millqvist, & Nordin, 2009; Nordin, Palmquist, & Claeson, 2013).

The health state of participants was assessed using the following definitions. Hypertension Stage 1 was defined as SBP between 130 and 139 mm Hg or DBP between 80 and 89 mm Hg (Whelton et al., 2018). Hypertension Stage 2 was defined as SBP ≥ 140 mm Hg or DBP ≥ 90 mm Hg (Whelton et al., 2018). Overweight was defined as BMI between 25 and 29 and obese as BMI ≥ 30 (Centers for Disease Control and Prevention [CDC], 2016). LDL ≥ 130 mg/dl was considered high, and HDL ≤ 40 mg/dl was considered low (Zwald, Akinbami, Fakhouri, & Fryar, 2017). Triglycerides of ≥150 mg/dl were considered elevated (Carroll, Kit, & Lacher, 2015). Prediabetes was defined as fasting glucose between 100 and 125 mg/dl or A1c between 5.7% and 6.4% (CDC, 2017). Diabetes was defined as fasting glucose >125 mg/dl or A1c > 6.4% (CDC, 2017). Moderate or worse depression severity was defined as a Patient Health Questionnaire-9 score ≥10 (Brody, Pratt, & Hughes, 2018).

Systemic inflammation was assessed via serum levels of C-reactive protein and the inflammatory cytokines interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor-α (TNF-α). Serum levels of Fetuin A (FA) and Amyloid P (SAP) were also assessed as markers of cardiovascular disease risk. Serum samples were analyzed in duplicate wells using the Milliplex MultiAnalyte Profiling Human CVD Panel 3 premixed kit (EMD Millipore Corp., Billerica, MA) for C-reactive protein, FA and SAP, and the Human High-Sensitivity T-Cell premixed kit (EMD Millipore Corp., Billerica, MA) for IL-1β, IL-6, IL-8, and TNF-α. The plates were read on a Luminex 200 analyzer (Luminex Corporation, Austin, TX) running Milliplex Analyst Version 5.1 software (Vigene Tech, Inc., Carlisle, MA). Concentrations for each biomarker were calculated in reference to a five-point best-fitting standard curve. Salivary cortisol levels were assessed using an enzyme immunoassay (Salimetrics, State College, PA).

Lifetime Stress Exposure

Cumulative count and severity of all of the acute and chronic stressors that participants experienced across the lifespan were measured with the Stress and Adversity Inventory for Adults (Adult STRAIN; Slavich & Shields, 2018). The STRAIN is an online system for assessing stressors occurring across the life course that may exert a cumulative effect on biological processes that promote disease. The STRAIN adheres to commonly agreed-upon best practices by assessing the specific timing of stress exposure, distinguishing between different forms and types of stress, and accounting for both “objective” exposure (i.e., counts) as well as “subjective” experiences (i.e., perceived stress severity; Slavich & Shields, 2018). Because the STRAIN produces a set of indices for multiple types of stressors (e.g., work, education, financial), it is ideally suited for the investigation of interactions between education-related stress and non-education-related stress among nursing students (see

Behaviors and Personal Traits

The frequency of consumption by food type (i.e., vegetables, fruit, sugary drinks), type and duration of physical activity (e.g., walking, swimming, running), smoking frequency, frequency of drug and alcohol consumption, sleep duration, and sleep quality was obtained via self-reports. Personality type, stress coping style, forgiveness, empathy, and self-efficacy were measured with the psychometric instruments listed in Supplemental Digital Content 1, Emotional intelligence was assessed using the Mayer–Salovey–Caruso Emotional Intelligence Test and cognitive ability was assessed using the overclaiming technique (Paulhus & Harms, 2004).

Social Factors

Socioeconomic status was assessed by maternal educational attainment, household income, poverty level, and median income of the census block group in which the participant resides. Childhood adversity was measured with the Adverse Childhood Experiences (ACE) questionnaire (Felitti et al., 1998). Social support (Mitchell et al., 2003) and attachment to parent and peers (Mattanah et al., 2011) were also assessed.

Engagement and Performance Endpoints

Burnout was measured using the Maslach Burnout Inventory (Maslach & Jackson, 1981; Yavuz & Dogan, 2014). The student version of the general survey (Maslach Burnout Inventory-General Survey for Students) was used at baseline and at first follow-up, and the human services survey was used at second follow-up. Academic performance was assessed via course grades, grade point average, and nursing licensure examination (NCLEX) results. Voluntary attrition from nursing program was used as a measure of engagement. After graduation, clinical performance was tracked with the Six Dimension Scale of Nursing Performance (Schwirian, 1978).

Environmental Exposures

Frequency and quantity of use of hazardous chemicals commonly encountered by nurses, including drugs (e.g., aerosolized antibiotics, antineoplastic drugs), sterilizers and disinfectants, anesthetic gases, and surgical smoke, was assessed with a modified version of the Health and Safety Practices Survey of Healthcare Workers (Steege, Boiano, & Sweeney, 2014). The type and frequency of personal care products used in daily life were assessed with a questionnaire modified from Wu et al. (2010). Exposure to green spaces was assessed via satellite imagery (Browning & Lee, 2017) and Google Streetview images based on geocoded addresses (Li, Deal, Zhou, Slavenas, & Sullivan, 2018). Serum levels of cadmium, aluminum, iron, copper, and arsenic were measured via inductively coupled plasma mass spectrometry (CDC, 2012; Funk, Pleil, Sauter, McDade, & Holl, 2015; Harkema et al., 2009).

Data Analysis

Descriptive statistics (e.g., means, standard deviations, and percentages) were used to describe the prevalence of common health conditions in the cohort, which in turn were compared against the national prevalence for adults between 20 and 39 years of age using the most recent data from the National Health and Nutrition Survey (CDC, 2018), unless otherwise specified. Biomarker (e.g., IL-1β, IL-6, IL-8, TNFα, FA, and SAP) and metal levels were transformed with a logarithmic function (base 10) and subsequently standardized. Odds ratios (ORs) were used as measures of associations between the life stress variables and unhealthy states (e.g., hypertension, obesity, depression). For life stress variables, tertiles were calculated and ORs were calculated for top versus bottom tertiles via binomial logistic regression. ORs were adjusted for age and gender based on evidence showing that these variables can affect associations between stress and health (Appelman, van Rijn, Ten Haaf, Boersma, & Peters, 2015; Mazure & Swendsen, 2016; Slavich & Irwin, 2014; Tamres, Janicki, & Helgeson, 2002). Analysis of covariance were used to characterize the variance of biomarkers (e.g., cytokines, A1c) across stress, behavioral, and environmental variables while controlling for age and gender.


Demographic and Behavioral Characteristics

At baseline, the cohort included 436 participants, 20% of whom were men, with an average age of 25.2 years old (SD = 2.3). Most participants self-identified as White (93%) and Hispanic (90%), and 20% were born outside the United States. Also, most participants (98%) were full-time students, just a few (4%) had a full-time job, 29% had a part-time job, 20% were living below the poverty line, and 20% were married. A small percentage of participants were current smokers (5%) or drank alcohol more than once a week (7%). Most participants ate fruits (79%) and vegetables (83%) at least twice a week. Although 86% of participants slept at least 7 hours on a typical night, 61% did not rate their sleep quality as good. Twenty-one percent of participants had an ACE score equal or greater than 4, which is 7 percentage points higher than in the general U.S. population (CDC, 2015). Descriptive statistics are provided in Supplemental Digital Content 2,

Lifetime Stress Exposure

Participants were exposed to an average of 14.8 stressors across the lifespan (SD = 10.7; range, 1–60; possible range, 0–166) as assessed by the Adult STRAIN, with an average overall severity score of 35.3 (SD = 26.0; range, 0–115; possible range, 0–265). When compared to students from the same university but enrolled in other majors (n = 1,186), nursing students experienced fewer total stressors over the life course, F(1, 1807) = 102.4, p < .001, with relatively lower cumulative lifetime severity, F(1, 1807) = 82.5, p < .001 (Figure 2). Students from other majors reported an average lifetime stressor count of 20.0 (SD = 12.3; range, 1–111) and an average overall cumulative lifetime stressor severity of 49.9 (SD = 30.3; range, 0–245). The variation of stressor count and severity scores across the primary life domains and core social–psychological characteristics assessed by the Adult STRAIN was similar and consistent with prior results (Slavich & Shields, 2018); therefore, we focused the main results on stressor counts.

Comparison of lifetime stressor exposure by stressor category for nursing and nonnursing male and female students. (A) Nursing students experienced a lower average total exposure to stressors across the lifetime than nonnursing students, F(1, 1511) = 49.63, p < .001. With respect to the life domains, female nursing students experienced more marital/partner stressors, F(1, 326) = 4.21, p = .041, and reproduction stressors, F(1, 326) = 8.35, p = .004, than male nursing students. (B) With respect to stress exposure across core social–psychological characteristics, there were no significant differences between female and male nursing students. Color image is available only in online version.

Women experienced an average of 15.3 stressors across the lifespan (SD = 10.2) as compared to 13.2 experienced by men (SD = 12.1, p = .15). The life stressors most commonly endorsed were from “Other Relationships” (23% by women, 25% by men) and “Marital/Partner” sources (21% by women, 18% by men; Figure 2A). With respect to the core social–psychological characteristics, the stressors most commonly experienced were “Interpersonal Loss” (27% by women, 30% by men) and “Role Change/Disruption” (23% by women, 21% by men; Figure 2B).

Across the lifespan, Hispanic participants experienced an average of 14.5 stressors (SD = 10.2) as compared to 17.3 (SD = 13.4) by non-Hispanics (p = .13). Participants with a full-time job experienced an average of 19.2 stressors across the lifespan (SD = 11.1) as compared to 15.5 (SD = 10.1) for those with a part-time job (p = .22) and 14.2 (SD = 10.9) for those without a job (p = .11). Participants younger than 25 years old experienced an average of 12.1 stressors across the lifespan (SD = 8.8), whereas those 25 years of age or older experienced an average of 19.6 stressors (SD = 12.0), with the difference between these groups being significant, F(1, 326) = 42.53, p < .001. Participants with an ACE score of 0 reported a significantly lower lifetime stress exposure (mean = 8.78, SD = 5.55) than participants with an ACE score of ≥4 (M = 25.1, SD = 12.4), F(1, 158) = 128.1, p < .001. A significant difference persisted when comparing the average lifetime stressor count of participants with ACE scores of ≥4 and those with ACE scores of <4 (M = 12.3, SD = 8.54), F(1, 325) = 94.72, p < .001.

Health Conditions at Baseline

The prevalence of Stage 2 hypertension in the NEWS cohort (9%) was similar to the national prevalence (8%). Overweight (24%) and obesity (20%) in the cohort was lower than the corresponding national prevalence (30% and 38%). The prevalence of high LDL levels (12%) and low HDL levels in the cohort (20%) was close to their respective national prevalence (12% and 21%, respectively). The prevalence of elevated triglycerides (34%) in the cohort was higher than the national prevalence (20%) among individuals between 20 and 39 years but was closer to the same prevalence among Hispanic women (28%) older than 20 years. Prediabetes prevalence (13%) was less than the national average (24%) among individuals between 18 and 44 years of age (CDC, 2017). The prevalence of moderate or worse depression severity (23%) was higher than the national prevalence (8%).

Compared to men, women in the NEWS cohort had lower odds of having hypertension (Stage 1 or 2), high LDL, low HDL, being overweight, or having diabetes (for ORs, see Figure 3; for summary statistics, see Supplemental Digital Content 3, Conversely, women had higher odds of being obese or having moderate or worst depression severity than men. Hispanics had lower odds of being diabetic and of suicidal ideation than non-Hispanics.

Odd ratios and 95% confidence intervals for selected health conditions by life stressor type and selected factors, adjusting for age and gender. Hypertension: Stage 1, systolic blood pressure 130–139 mm Hg or diastolic blood pressure 80–89 mm Hg; Stage 2, systolic blood pressure ≥ 140 mm Hg or diastolic blood pressure ≥ 90 mm Hg. High low-density lipoproteins levels ≥ 130 mg/dl, low high-density lipoproteins levels ≤ 40 mg/dl, elevated triglycerides ≥ 150 mg/dl. Overweight, body mass index 25–29; obesity, body mass index ≥ 30. Prediabetes, fasting glucose 100–125 mg/dl or glycated hemoglobin (A1c) 5.7%–6.4%; diabetes fasting glucose ≥ 125 mg/dl or A1c ≥ 6.4%. Depression, Patient Health Questionnaire-9 score ≥ 10, which represents moderate or worse severity. TT = top tertile; BT = bottom tertile. p < .10, *p < .05, **p < .01, ***p < .001. ° = unadjusted.

Several patterns of associations between participants’ life stress exposure and health conditions were observed (for ORs, see Figure 3; for summary statistics, see Supplemental Digital Content 3, Participants with high early life stress exposure (stressor counts in the top tertile) or with ACE scores of ≥4 had lower odds of having elevated triglycerides as compared to participants with low early life stress exposure (stressor counts in the bottom tertile) or to participants with an ACE score equal to zero, respectively. Compared to low lifetime exposure to marital/partner stressors, high lifetime exposure to marital/partner stressors was associated with greater odds of both Stage 1 and Stage 2 hypertension (see Figure 3). Similarly, elevated triglycerides were positively associated with lifetime exposure to education, work, and reproductive stressors. Being overweight was positively associated with stress exposure during adulthood, as well as with lifetime exposure to education, work, marital/partner, and legal/crime stressors. Being obese was positively associated with lifetime exposure to reproductive, legal/crime, and possessions stressors (see Figure 3). Moderate or worst depression was positively associated with total lifetime stress exposure, early life stress exposure and ACE scores of ≥4, and lifetime stressors involving housing, treatment/health, other relationships, entrapment, and role change/disruption.

Biomarker Levels

The analysis of covariance also revealed several significant associations between participants’ lifetime stress exposure and biomarker levels (for detailed results, see Supplemental Digital Content 4, and Supplemental Digital Content 5, For instance, IL-8 was positively associated with stress exposure across the lifespan, F(1, 208) = 4.37, p = .038, as well as with lifetime exposure to financial, F(1, 208) = 5.16, p = .024, and life-threatening situation stressors, F(1, 209) = 4.09, p = .045. IL-6 was negatively associated with lifetime exposure to housing, F(1, 209) = 3.57, p = .060; education, F(1, 207) = 3.37, p = .068; and reproductive stressors, F(1, 206) = 3.06, p = .082. TNF-α was negatively associated with lifetime exposure to housing, F(1, 209) = 3.61, p = .059; education, F(1, 207) = 4.66, p = .032; work, F(1, 208) = 3.11, p = .079; and possessions stressors, F(1, 206) = 3.69, p = .056. Lifetime exposure to possession stressors was also negatively associated with IL-8 F(1, 206) = 2.74, p = .099.

CIMT was positively associated with lifetime exposure to stressors from multiple sources, including housing, F(1, 202) = 9.97, p = .002; education, F(1, 198) = 9.53, p = .002; work, F(1, 207) = 10.43, p = .001; reproductive, F(1, 198) = 18.42, p < .001; financial, F(1, 206) = 7.83, p = .006; legal, F(1, 198) = 13.83, p < .001; and possessions, F(1, 197) = 11.76, p < .001. RBC was negatively associated with lifetime stress exposure, F(1, 34) = 3.53, p = .069, stress exposure occurring during both early life, F(1, 31) = 4.36, p = .045, and adulthood, F(1, 34) = 5.02, p = .032, as well as with lifetime exposure to housing, F(1, 34) = 5.94, p = .023; marital/partner, F(1, 34) = 7.87, p = .008; and financial stressors, F(1, 34) = 8.23, p = .012. Lifetime exposure to stressors involving treatment/health was positively associated with lymphocyte, F(1, 22) = 5.57, p = .028, and basophil counts, F(1, 22) = 7.08, p = .014. Finally, ACE score was negatively associated with WBC, F(1, 33) = 4.98, p = .033, and RBC, F(1, 33) = 4.06, p = .052, as well as with neutrophil, F(1, 33) = 4.05, p = .052, and monocyte counts, F(1, 33) = 6.51, p = .016.


These results represent one of the most comprehensive summaries of the lives and health of nursing students to date. Prevalence of most health conditions measured at baseline in the NEWS cohort was comparable—and sometimes better—than the U.S. population. The prevalence of moderate-to-severe depression in the cohort was comparable to the prevalence (26%) among North American nursing students estimated via meta-analysis (Tung, Lo, Ho, & Tam, 2018) and might be partially explained by the fact that our cohort is predominately young, Hispanic, and female. Evidence shows that females (World Health Organization, 2012), Hispanics (Shattell, Smith, Quinlan-Colwell, & Villalba, 2008), and college students (Buchanan, 2012) are particularly susceptible to depression. NEWS participants also reported fewer lifetime stressors than students from all other majors at the same university and approximately half as many lifetime stressors—with approximately half the total severity—as was recently reported in a nationwide assessment of adults who completed the STRAIN (Slavich & Shields, 2018).

Although NEWS participants generally exhibited relatively good health, there was substantial variability in health risk factors, thus supporting the need to assess factors that might predict disease risk on an individual basis. For example, elevated exposure to lifetime stressors was associated with greater risk of hypertension, diabetes, and depression. More education-related stressors, in turn, were associated with elevated triglycerides, BMI, and CIMT, but also with lower inflammation (e.g., TNF-α).

The relevance of investigating the effects of life stress and other factors on health trends in young adults—especially among high-stress exposure groups such as nursing students—is supported by studies showing that health during early life and young adulthood affects lifespan risk for health problems. For example, a case–control study found that depressive disorders often emerge in childhood and continue through the adult life (Harrington, Fudge, Rutter, Pickles, & Hill, 1990). Likewise, a longitudinal study revealed that cardiovascular risk factors such as blood pressure and cholesterol levels in early adulthood predicted subsequent risk of cardiovascular disease in older adulthood (Pletcher, Vittinghoff, Thanataveerat, Bibbins-Domingo, & Moran, 2016).

Among nursing students specifically, it is unclear how health conditions that are present during nursing school affect, or are affected by, the transition into the work environment and what role stress plays in structuring these effects. It is important to determine the extent to which health risks, susceptibilities, and psychosocial assets persist into the early stages of the nursing profession. Moreover, if these factors persist into the work environment, it will be important to understand how these factors interact and how they moderate or mediate the effects of lifetime stress exposure on health.

Strengths and Limitations

Several strengths and limitations of this study are noteworthy. For example, although we only report baseline data in the present article, the NEWS cohort provides a prospective cohort study design, which permits the examination of how early life stressors—as well as behavioral, social, and environmental factors—affect young nurses’ susceptibility and resilience to stress in the workforce. Also, because most students at University of Texas at El Paso progress through the BSN program as a cohort and hence experience the same coursework and similar clinical experiences, the NEWS supports the assessment of students’ sensitivity to education-related stress and modifying factors as they progress through the program. In contrast, an important limitation to the NEWS is the temporal discordance of some assessments. We plan to account for measures that are not perfectly aligned in time by relying on assessment dates, course, and clinical training schedules and by asking participants to report on historic data in questionnaires (e.g., “in the last 2 weeks…”). Still, we might not be able to overcome the fact that some measures are collected at different times in some important analyses. In these cases, the interpretation of results will account for this discordance. Another limitation of the NEWS is that some analyses might fail to properly reject the null hypothesis of no gender effect, given the limited number of males in the cohort.

Importantly, the observations from this study were drawn from a cohort that is predominately Hispanic (90%), with a substantial proportion being foreign-born (20%). Baseline measures and observed associations may thus not apply to the general population of nursing students across the United States, which in 2014 included 28% racial-ethnic minorities, 8% Hispanics, and 4% foreign-born (National League for Nursing, 2014). For instance, minority populations (American Psychological Association, 2017) as well as foreign-born nursing students (Vardaman & Mastel-Smith, 2016) experience higher levels of stress as compared to Whites and U.S.-born students, respectively. Evidence also shows that Hispanics are at higher risk than non-Hispanics of developing health problems (e.g., diabetes) that are typically associated with stress exposure (CDC, 2004).

Despite these shortcomings, the results of this study are valuable as they represent one of the most comprehensive studies on Hispanics and foreign-born nursing students to date. Studying the stress–health relationship in this group of future nurses is timely and relevant, as both the U.S. population and the healthcare force in the United States are rapidly becoming more diverse (Patel, Ly, Hicks, & Jena, 2018).


In conclusion, as the U.S. population ages and the incidence of chronic illness continues to rise, ensuring the availability of a competent nursing force to deal with these challenges will be a central challenge for healthcare systems. Meeting this demand will be difficult if the present shortage of nurses persists. Indeed, workforce problems could get worse if work-related stressors increase and affect the prevalence of major health problems in new nurses. Likewise, it is urgent that we enhance the learning and working environments of registered nurses in ways that increase their capacity to attain and conserve physical and psychological well-being. These efforts will help improve the long-term health and well-being of nurses, as well as reduce turnover and attrition in hospitals.

Given the unique demographic composition of its cohort, we believe that the NEWS will result in important contributions to these efforts by identifying factors that could be targeted by schools of nursing and healthcare institutions to minimize the effect of stress on young Hispanic male and female nurses. Indeed, understanding how young Hispanic nurses respond to, and are affected by, life stress is timely and relevant. Institutions like the Health Resources and Services Administration’s Division of Nursing and the National Institute of Nursing Research are striving to diversify the nursing profession to respond to healthcare needs and disparity-associated challenges of a diversifying U.S. population, and additional research is warranted to help ensure the sustained good physical health, psychological wellness, and productivity of this workforce.



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