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You routinely administer combination drugs…

GEVER, MARCY PORTNOFF PHARMD, MED

DRUG CHALLENGE
Free

but do you know what's in them? To find out, match each combination of ingredients in Section II with its correct name in Section I.

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SECTION I

__________1. Synercid (Monarch Pharmaceuticals)

__________2. Benicar HCT (Sankyo)

__________3. Excedrin (Bristol-Myers Squibb)

__________4. Triphasil (Wyeth)

__________5. Vytorin (Merck/Schering-Plough)

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SECTION II

  1. after reconstitution, each 10 ml contains: quinupristin, 150 mg, 180 mg; dalfopristin, 350 mg, 420 mg
  2. This combination antibiotic is administered I.V. to treat life-threatening bacteremia due to vancomycin-resistant Enterococcus faecium. Both quinupristin and dalfopristin are antibiotics. Adverse drug reactions include infusion-site reactions and hyperbilirubinemia.
  3. olmesartan medoxomil, 20 mg, 40 mg; hydrochlorothiazide, 12.5 mg, 25 mg
  4. Used to treat hypertension, this combination contains olmesartan, an angiotensin II receptor antagonist, and hydrochlorothiazide, a diuretic. Tell your patient to drink enough fluids and to promptly report adverse reactions such as light-headedness. Angioedema is a rare adverse reaction. Tell her to stop the drug and call 911 if her eyes or lips swell or she has difficulty breathing.
  5. levonorgestrel, 0.05 mg, 0.075 mg, 0.125 mg; ethinyl estradiol, 0.03 mg, 0.04 mg
  6. Each oral contraceptive cycle consists of three different dosage phases of the synthetic progestogen levonorgestrel and the estrogen ethinyl estradiol to mimic the hormone levels of a normal menstrual cycle. Tell your patient to take the tablets in the correct order: brown, white, then light yellow, followed by the inert light green tablets.
  7. acetaminophen, 250 mg; aspirin, 250 mg; caffeine, 65 mg
  8. This migraine headache combination contains the non-opioid analgesics acetaminophen and aspirin. Caffeine enhances their effects. Warn parents not to give this combination to children or teenagers with flu symptoms because aspirin increases the risk of Reye's syndrome.
  9. simvastatin, 10, 20, 40, or 80 mg; ezetimibe, 10 mg
  10. This lipid-lowering combination contains simvastatin, a statin drug, and ezetimibe, which inhibits the absorption of cholesterol in the small intestine. Instruct your patient to take this medication in the evening for best results.

Marcy Portnoff Gever is an independent pharmacist consultant and educator in Ringoes, N.J.

© 2005 Lippincott Williams & Wilkins, Inc.