ArticleComorbid HIV Infection and Opioid Use Disorder Simulation for Nurse Practitioner StudentsWoroch, Ruth A. DNP, RN, CHSE; Chu, Minseung DNP, RN; Gingell, Monica J. DNP, RN Author Information Clinical Assistant Professor (Drs Woroch and Chu) and Visiting Clinical Instructor (Dr Gingell), Population Health Nursing Science, University of Illinois at Chicago. Correspondence: Dr Woroch, Population Health Nursing Science, University of Illinois at Chicago, 845 S. Damen, Chicago, IL 60612 ([email protected]). The authors declare no conflicts of interest. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's website (www.nurseeducatoronline.com). Accepted for publication: June 19, 2022 Early Access: July 19, 2022 Cite this article as: Woroch RA, Chu M, Gingell MJ. Comorbid HIV infection and opioid use disorder simulation for nurse practitioner students. Nurse Educ. 2022;00(0):1-4. doi:10.1097/NNE.0000000000001271 Nurse Educator: July 19, 2022 - Volume - Issue - 10.1097/NNE.0000000000001271 doi: 10.1097/NNE.0000000000001271 Buy SDC PAP Metrics Abstract Background: Human immunodeficiency virus (HIV) infection and opioid use disorder (OUD) often occur as comorbid conditions. Many nurse practitioners are treating these conditions in their practice. Problem: Most advanced practice registered nursing (APRN) students do not encounter a medically complex patient with both HIV infection and OUD during their clinical experiences. Approach: We present an unfolding simulated standardized patient scenario involving both HIV infection and OUD for APRN students. During each of 3 semesters, the students encounter the patient as he presents for a sexually transmitted infection, an OUD relapse, and, finally, new-onset HIV infection. The scenarios become increasingly complex as the students progress in their clinical experiences. Conclusion: This innovative series of scenarios introduces APRN students to complex comorbid patient situations, with many issues to consider. © 2022 Wolters Kluwer Health, Inc. All rights reserved.