The Technology Informatics Guiding Education Reform (TIGER) Initiative is designed to address a set of skills that is needed by all nurses who will practice in the profession in the 21st century. The skill set includes informatics competencies that range from basic computer skills to advanced-level information technology and literacy competencies and expertise. Despite the significance of the TIGER Initiative, few nurse educators have operationalized TIGER or adopted its plan to transform nursing practice and education to better prepare nurses to practice in a technology rich healthcare environment. TIGER is currently in phase III: implementation. The authors outline the TIGER Initiative as well as actions that nurse educators can take to develop and integrate informatics competencies into the curriculum to prepare nurses for the high-touch, high-technology patient-centered care of the 21st century.