Original Paper188Re-tin-colloid as a new therapeutic agent for rheumatoid arthritisLEE, EB1,2; SHIN, KC1,2; LEE, YJ1,2; LEE, YJ3; CHEON, GJ3; JEONG, JM3,4; SON, MW5; SONG, YW1,2Author Information 1Department of Internal Medicine, 2Medical Research Center, 3Department of Nuclear Medicine and 4Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea and 5Dong-A Pharmaceutical Company, Seoul, South Korea Address all correspondence to Yeong Wook Song, Department of Internal Medicine, Seoul National University College of Medicine, 28 Yungon-dong, Chongno-gu, Seoul 110-744, South Korea. Tel.: 822-760-2234. Fax: 822-762-9662. E-mail: email@example.com Received 11 July 2002, in revised form 28 August 2002 and accepted 26 November 2002 Nuclear Medicine Communications: June 2003 - Volume 24 - Issue 6 - p 689-696 Buy Abstract Radiation synovectomy is a useful treatment modality in patients with refractory synovitis. We have developed a 188Re-tin-colloid as a new radiopharmaceutical agent and investigated its efficacy and safety in patients with rheumatoid arthritis. Radiation synovectomy was performed using 188Re-tin-colloid in 22 knees from 21 rheumatoid arthritis patients refractory to intra-articular corticosteroid injection. The efficacy and safety of administration of 370-1110 MBq of 188Re-tin-colloid were evaluated after 1, 3, 6, 9 and 12 months. Pain intensity on a visual analogue scale decreased significantly 12 months after therapy (mean±SD: 68.0±26.1 mm vs. 25.1±23.4 mm; P = 0.0001 by the paired t-test). Pain decreased in 19 cases (86.3%), joint tenderness improved in 14 cases (63.6%) and joint swelling was reduced in all cases (100%). 188Re-tin-colloid was safe. The residual activity of 188Re in the blood was 0.077%±0.25% of the injected dose. The radioactivity of 188Re in the urine was 0.14%±0.13% of the injected dose. Transient reactive synovitis was observed in 18 cases (81.8%). No clinical side-effects or abnormalities in leucocyte count, platelet count, liver function tests or urine analysis were observed in any patient. In conclusion, in this first study of radiation synovectomy using 188Re-tin-colloid for patients with rheumatoid arthritis, the treatment resulted in the improvement of arthritis and was well tolerated. © 2003 Lippincott Williams & Wilkins, Inc.