Technical NoteEnhancing capacity and synthesis of [68Ga]68-Ga-PSMA-HBED-CC with the lyophilized ready-to-use kit for nuclear pharmacy applicationsGolan, Haima,,b; Esa, Moadc; Moshkoviz, Kerenc; Feldhaim, Asherd; Hoch, Baruchd; Shalom, ElidAuthor Information aTheranostics and Molecular Imaging, Isotopia Molecular Imaging LTD bQuality Assurance Department, Isotopia Molecular Imaging LTD cRadiopharmacy Department, Isotopia Molecular Imaging LTD dResearch and Development Department, Isotopia Molecular Imaging LTD, 39 Alexander Yanay St., Petach Tikva, Israel Received 26 January 2020 Accepted 12 May 2020 Correspondence to Haim Golan, MD, 39 Alexander Yanay St., Petach Tikva, Israel, Tel: +972 537346145; fax: +972 39300667; e-mail: firstname.lastname@example.org Nuclear Medicine Communications: September 2020 - Volume 41 - Issue 9 - p 986-990 doi: 10.1097/MNM.0000000000001232 Buy Metrics Abstract Introduction The authors describe the newly proposed synthesis technique for the gallium-68 (Ga-68)-labeled tracer ([68Ga]Ga-PSMA-HBED-CC) for imaging expression of the prostate-specific membrane antigen (PSMA). An effort was applied to design the lyophilized cold kit (isoPROtrace-11) as a time-saving technique resulting in increased radiochemical yields. Procedures The initial material for labeling was obtained from a 68Ge/68Ga-generator. For labeling with the lyophilized cold kit isoPROtrace-11, 2.5 ml 0.1 M HCl of the middle Ga-68 elution fraction were added to the kit, shook for dissolving the vial’s contents and kept for 5 minutes at room temperature. A systematic comparison was carried out between results obtained with the cold kit technique and with previously used Modular-Lab module concerning the radiochemical yield, purity, and the time of producing. Results Automated module-involved synthesis of [68Ga]Ga-PSMA-HBED- CC resulted in a radiochemical yield of 84.2 ± 6.3% and purity of >95% after 25 minutes. The room temperature cold kit gave a radiochemical yield of >98% and purity of >95% after 5 minutes. Conclusion Using the kit method reduced the labeling time. The cold kit method increased production efficiency because less of the eluted Ga-68 was wasted. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.