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Role of 18F-flurodeoxyglucose in orthopaedic implant-related infection

review of literature and experience

Bhoil, Amit; Caw, Hendrick; Vinjamuri, Sobhan

doi: 10.1097/MNM.0000000000001063
Review Article

Infection and inflammation are a common occurrence with orthopaedic procedures. Anatomical modalities can show the transformation in the disease process; however, these may occur later when compared with functional imaging modalities that are more likely to identify early disease patterns. Various molecular imaging modalities such as three-phase bone scintigraphy, labelled leucocyte scintigraphy, as well as radiolabelled antibiotics and immunoglobulins have been considered and have played key roles in assisting clinical decision-making. While 18F-flurodeoxyglucose (FDG) PET/computed tomography (CT) has been relatively well established in cancer pathways, it has the potential to contribute to surgical decision making for possible osteomyelitis post-metal implant surgery. In this article, we present a review of recently used tracers, and share our experience with using 18F-FDG PET/CT studies in a few diverse clinical settings related to post-metal implant osteomyelitis.

Department of Nuclear Medicine, Royal Liverpool University Hospital, Liverpool, UK

Received 21 June 2019 Accepted 22 June 2019

Correspondence to Amit Bhoil, MD, Department of Nuclear Medicine, Royal Liverpool University Hospital, L7XP, Liverpool, UK, Tel: + 44 151 706 4462; fax: + 44 151 706 5844; e-mail:

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