ORIGINAL ARTICLESCan 18F-FDG PET/CT diagnose malignant change in benign chondroid tumors?Purandare, Nilendu C.a; Puranik, Ameyaa; Shah, Snehaa; Agrawal, Archia; Puri, Ajayb; Gulia, Ashishb; Nayak, Prakashb; Rekhi, Bharatc; Rangarajan, VenkateshaAuthor Information Departments of aNuclear Medicine and Molecular Imaging bOrthopedic Oncology cPathology, Tata Memorial Centre, Homi Bhabha National Institute (HBNI), Mumbai, Maharashtra, India Correspondence to Nilendu C. Purandare, DNB, DMRD, Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Centre, Homi Bhabha National Institute (HBNI), Mumbai, Maharashtra 400012, India Fax: +91 222 414 6937; e-mail: firstname.lastname@example.org Received January 2, 2019 Received in revised form February 6, 2019 Accepted March 18, 2019 Nuclear Medicine Communications: June 2019 - Volume 40 - Issue 6 - p 645-651 doi: 10.1097/MNM.0000000000001015 Buy Metrics Abstract Aim The aim of this study was to determine whether fluorine-18 fluorodeoxyglucose (18F-FDG) PET/computed tomography (CT) can diagnose malignant change in benign chondroid tumors. Patients and methods This study included patients with clinicoradiological features of a chondroid tumor who were referred for a 18F-FDG PET/CT study to evaluate clinical suspicion of malignant change. Metabolic characteristics of the suspected lesion in the form of maximum standardized uptake value (SUVmax) was obtained and compared with histopathology. In patients who were treated conservatively and for whom histopathology was not available, stability of the lesion on clinical/radiological follow-up was used as reference standard. Receiver operating characteristic curve analysis was performed to obtain a SUVmax cutoff value to differentiate between benign and malignant lesions. Results Clinical and imaging data of 66 patients was available for analysis. Malignancy was confirmed by histopathology in 40/66 (60.6%) patients with grade 2 chondrosarcomatous change seen in majority. In 26 patients, the final diagnosis was benign tumor (osteochondroma, n=19; enchondroma, n=7). Median SUVmax of malignant lesions was significantly higher compared with the benign lesions (4.0 vs. 2.1, P=0.00). A SUVmax cutoff of 3.1 could differentiate a benign lesion from those with malignant transformation with a sensitivity of 90.3% and specificity of 87% (area under the curve=0.92). Dedifferentiated sarcomas showed a significantly higher uptake than rest of the sarcoma types. Conclusion 18F-FDG PET/CT can detect malignant change in benign chondroid neoplasms by showing higher metabolic activity in the area of sarcomatous transformation. It can also identify focus of dedifferentiation which has prognostic and therapeutic implications. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.