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Standardization of the specific binding ratio in [123I]FP-CIT SPECT

study by striatum phantom

Kita, Akinobua,b; Onoguchi, Masahisab,c; Shibutani, Takayukib,c; Horita, Hirokazuf; Oku, Yasuhirog; Kashiwaya, Souichiroud; Isaka, Masatoe; Saitou, Masakih

Nuclear Medicine Communications: May 2019 - Volume 40 - Issue 5 - p 484–490
doi: 10.1097/MNM.0000000000001010

Objective The quantitative values of the specific binding ratio (SBR) in [123I]FP-CIT have been reported to change because of differences in apparatus, collection conditions, and image reconstruction. The aim of this study was to clarify the distribution of calculated SBR values by performing [123I]FP-CIT single-photon emission computed tomography in a multicenter collaborative study using a phantom. A simple correction method was also devised that enables direct comparison of the SBR value calculated at one facility with those calculated at other facilities.

Materials and methods Data were acquired at 14 facilities using the phantom adjusted to right striatum : left striatum : cerebral parenchyma (back ground)=8 : 4 : 1, and the SBR values were calculated.

We devised a method to correct the SBR using the results of experiments with a known ratio phantom.

Results The SBR values considerably differed between facilities. The average SBR with a theoretical value of 7 and with a theoretical value of 3 in all facilities was 6.48±0.89 and 2.58±0.51, respectively. The range of SBRs with a theoretical value of 7 and a theoretical value of 3 was 3.18 and 1.59, respectively. We devised a simple method for calibrating the SBR value at the clinical examination of each facility to a directly comparable value.

Conclusion Direct comparison of the SBR with those of other facilities and sharing other facilities normal values is clinically difficult. We devised countermeasures that do not affect the diagnosis and developed a simple tool to calculate the standardized SBR.

aRadiological Center, University of Fukui Hospital, Fukui

bDepartment of Quantum Medical Technology, Graduate School of Medical Sciences

cDepartment of Quantum Medical Technology, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University

dDepartment of Radiology, Municipal Kanazawa Hospital

eDepartment of Radiology, Asanogawa General Hospital, Kanazawa

fDepartment of Radiology, Toyama University Hospital, Toyama

gDepartment of Diagnostic Imaging, Kouseiren Takaoka Hospital, Takaoka

hDepartment of Radiology, Municipal Tsuruga Hospital, Tsuruga, Japan

Correspondence to Masahisa Onoguchi, PhD, Department of Quantum Medical Technology, Graduate School of Medical Sciences, Kanazawa University, Kodatsuno 5-11-80, Kanazawa, Ishikawa 920-0942, Japan Tel/fax: +81 762 652 526; e-mail:

Received December 30, 2018

Received in revised form February 23, 2019

Accepted February 25, 2019

Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.