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The efficacy of fluorine-18-choline PET/CT in comparison with 99mTc-MIBI SPECT/CT in the localization of a hyperfunctioning parathyroid gland in primary hyperparathyroidism

Araz, Minea; Soydal, Çiğdema; Özkan, Elgina; Kir, Metin K.a; İbiş, Erkana; Güllü, Sevimb; Erdoğan, Murat F.b; Emral, Rifatb; Küçük, Özlem N.a

doi: 10.1097/MNM.0000000000000899

Aim The aim of this study was to determine the role of fluorine-18-choline (18F-FCH) PET/CT in comparison with technetium-99m-methoxyisobutylisonitrile (99mTc-MIBI) single-photon emission computed tomography/computed tomography (SPECT/CT) in primary hyperparathyroidism and to investigate whether maximum standardized uptake value (SUVmax) may be indicative of disease severity.

Patients and methods Thirty-five primary hyperparathyroidism patients (24 females, 11 males, mean age: 55.31±12.27, range: 25–72 years) who underwent 99mTc-MIBI SPECT/CT and 18F-FCH PET/CT and had inconclusive neck ultrasonography (USG) were studied. The diagnostic power of both modalities and the relationship between SUVmax and biochemical [serum parathormone (PTH), calcium, phosphorus, vitamin D3 levels, urinary calcium excretion/24 h] and clinical (bone mineral densitometry and urinary USG results) parameters were analyzed.

Results In 29 of 35 patients, 99mTc-MIBI SPECT/CT and 18F-FCH were concordant (κ=0.64, P=0.001). In five of 35 patients with a negative SPECT/CT, 18F-FCH PET/CT accurately localized parathyroid adenomas. In one patient, 18F-FCH was false negative and 99mTc-MIBI SPECT/CT showed the lesion. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 99mTc-MIBI SPECT/CT and 18F-FCH PET/CT were calculated to be 78, 100, 100, 70, 86%, and 96, 100, 100, 93, and 97%, respectively. SUVmax was correlated with lumbal T scores (P=0.026). The mean serum PTH levels were significantly higher (P=0.026) and lumbal and femur T scores were significantly lower (P=0.04 and 0.008) in patients with SUVmax greater than 4.4 (i.e. the mean SUVmax calculated in positive cases).

Conclusion 18F-FCH PET/CT has a high diagnostic power in primary hyperparathyroidism and can be used for further evaluation of patients with inconclusive neck USG and 99mTc-MIBI SPECT/CT. SUVmax of the hyperfunctioning parathyroid gland seems to be predictive of disease severity in terms of serum PTH and bone mineral densitometry results. Studies with larger patient groups are needed to support these data.

Departments of aNuclear Medicine

bEndocrinology and Metabolism Diseases, Medical Faculty, Ankara University, Ankara, Turkey

Correspondence to Mine Araz, MD, Department of Nuclear Medicine, Medical Faculty, Ankara University, Cebeci Hospital, Ankara, Turkey Tel: +90 532 666 7313; fax: +90 312 362 0897; e-mail:

Received March 14, 2018

Received in revised form May 24, 2018

Accepted July 30, 2018

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