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Correlation of radiation dose and activity with clinical outcomes in metastatic colorectal cancer after selective internal radiation therapy using yttrium-90 resin microspheres

Badiyan, Shaheda; Bhooshan, Nehad; Chuong, Michael D.f; Sharma, Naveshe; Akhter, Nabeelb; Etezadi, Vahidb; Hausner, Petrc; Kudryasheva, Svetlanaa; Kaiser, Adeela; Becker, Stewarta; Guerrero, Marianaa; Yi, Byong Y.a

Nuclear Medicine Communications: October 2018 - Volume 39 - Issue 10 - p 915–920
doi: 10.1097/MNM.0000000000000887
ORIGINAL ARTICLES
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Purpose Yttrium-90 (90Y)-resin microspheres are prescribed using activity. We evaluated overall survival (OS) and radiographic tumor response after selective internal radiation therapy (SIRT) with resin microspheres in patients with liver metastases from colorectal cancer.

Patients and methods We retrospectively reviewed 60 metastatic colorectal cancer patients treated at our institution with SIRT using 90Y-resin microspheres. Each patient underwent pre-SIRT MRI or computed tomography imaging of the liver with intravenous contrast. Patients underwent post-treatment imaging at 2–3-month intervals with response assessed according to unidimensional Response Evaluation Criteria in Solid Tumors (RECIST) criteria as well as published three-dimensional volumetric criteria. We then related the prescribed activity established by the body surface area method and the corresponding prescribed dose to radiographic treatment response and OS.

Results The median follow-up after the first SIRT treatment was 8.9 months. The mean prescribed activity and the prescribed dose were 26.6 mCi and 52.8 Gy, respectively. OS was not significantly associated with either prescribed activity or prescribed dose. Prescribed dose was also not related to response. However, a significant relationship was found between a higher prescribed activity and an improved radiographic response by RECIST (P=0.04) at the second follow-up.

Conclusion The prescribed activity of 90Y-resin microspheres may be correlated with radiographic response by RECIST criteria at 4–6 months post-treatment. For a more accurate prediction of response, a valid dose calculation model based on post-90Y PET dosimetry is likely needed given the heterogeneous dose delivery seen in SIRT.

Departments of aRadiation Oncology

bDiagnostic Radiology and Nuclear Medicine

cDivision of Medical Oncology, University of Maryland School of Medicine, Baltimore, Maryland

dUPMC Pinnacle Health Radiation Oncology, Harrisburg

eDepartment of Radiation Oncology, Penn State Health, Milton S. Hershey Medical Center, Hershey, Pennsylvania

fMiami Cancer Institute at Baptist Health South Florida, Miami, Florida, USA

Data were presented previously at the ASTRO annual meeting and published as an abstract in Int J Radiat Oncol Biol Phys 2014; 1:s381.

Correspondence to Byong Y. Yi, PhD, Department of Radiation Oncology, University of Maryland Medical Center, 22 South Greene Street, Baltimore, MD 21201, USA Tel: +1 410 328 6080; fax: +1 410 328 5279; e-mail: byi@umm.edu

Received March 23, 2018

Received in revised form June 29, 2018

Accepted July 6, 2018

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