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Comparison of gamma camera-based methods to measure glomerular filtration rate in potential kidney donors

Saeed, Shabanaa; Saeed, Smeeraa; Khawar, Ambreena; Yousuf, Mohammada; Bukhari, Tauseefb; Sohaib, Muhammada

Nuclear Medicine Communications: May 2015 - Volume 36 - Issue 5 - p 481–485
doi: 10.1097/MNM.0000000000000280
ORIGINAL ARTICLES
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Introduction The aim of this study was to compare two gamma camera-based methods (Gates’ method and Inoue’s method) for measuring glomerular filtration rate (GFR) with Russell’s two plasma sample clearance method (2-PSC), which was taken as the gold standard.

Materials and methods In 94 healthy potential kidney donors (25 women and 69 men), GFR was measured by means of the 2-PSC method and was compared with Gates’ and Inoue’s methods of assessing GFR after technetium-99m-labeled diethylene triamine penta-acetic acid (99mTc-DTPA) injection.

Results Inoue’s method showed no statistically significant difference (P=0.22) with the gold standard (2-PSC); there was good correlation (r=0.69) and least bias (−1.91 ml/min/1.73 m2, root mean squared error=11.85 ml/min/1.73 m2). Gates’ method showed weak correlation (r=0.36) and tended to underestimate GFR by 21% with bias of 25 ml/min/1.73 m2 and root mean squared error of 29.97.

Conclusion For a normal healthy adult population, Inoue’s method gives a better measure of GFR in contrast to Gates’ method when compared with 2-PSC method of GFR calculation.

aDepartment of Medical Sciences, Pakistan Institute of Engineering and Applied Sciences, Islamabad

bThe Kidney Centre, Rawalpindi, Pakistan

Correspondence to Shabana Saeed, FCPS, MS, MBBS, Department of Medical Sciences, Pakistan Institute of Engineering and Applied Sciences (PIEAS), PO Nilore, Islamabad 45650, Pakistan Tel: +92 51 9248728; fax: +92 51 2208070; e-mails: shabana_saeed@yahoo.com, shabana@pieas.edu.pk

Received May 15, 2014

Received in revised form December 16, 2014

Accepted January 5, 2015

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