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Nuclear medicine in the management of patients with heart failure: guidance from an expert panel of the International Atomic Energy Agency (IAEA)

Peix, Amaliab; Mesquita, Claudio Tinococ; Paez, Dianaa; Pereira, Carlos Cunhad; Felix, Renatae; Gutierrez, Claudiag; Jaimovich, Rodrigoi; Ianni, Barbara Mariaf; Soares, Jose Jrf; Olaya, Pastorh; Rodriguez, Ma. Victoriaj; Flotats, Albertk; Giubbini, Raffaelel; Travin, Markm; Garcia, Ernest V.n

Nuclear Medicine Communications: August 2014 - Volume 35 - Issue 8 - p 818–823
doi: 10.1097/MNM.0000000000000143
Review Articles

Heart failure is increasing worldwide at epidemic proportions, resulting in considerable disability, mortality, and increase in healthcare costs. Gated myocardial perfusion single photon emission computed tomography or PET imaging is the most prominent imaging modality capable of providing information on global and regional ventricular function, the presence of intraventricular synchronism, myocardial perfusion, and viability on the same test. In addition, 123I-mIBG scintigraphy is the only imaging technique approved by various regulatory agencies able to provide information regarding the adrenergic function of the heart. Therefore, both myocardial perfusion and adrenergic imaging are useful tools in the workup and management of heart failure patients. This guide is intended to reinforce the information on the use of nuclear cardiology techniques for the assessment of heart failure and associated myocardial disease.

aDepartment of Nuclear Sciences and Applications, Division of Human Health, Section of Nuclear Medicine and Diagnostic Imaging, International Atomic Energy Agency, Vienna, Austria

bInstituto de Cardiología y Cirugía Cardiovascular, Havana, Cuba

cHospital Universitário Antonio Pedro, Universidade Federal Fluminense (UFF), Niteroi

dQuanta Diagnostico Nuclear, Curitiba

eInstituto Nacional de Cardiologia, Rio de Janeiro

fInstituto do Coração, Universidade de São Paulo, São Paulo, Brazil

gFundación Cardioinfantil, Instituto de Cardiología, Bogotá

hFundación Clínica Valle Del Lili, Cali, Colombia

iHospital Clínico, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile

jHospital General de Coro, Coro, Venezuela

kUniversitat Autònoma de Barcelona, Department of Nuclear Medicine Hospital de la Santa Creu i Sant Pau, Barcelona, Spain

lCattedra e U.O. di Medicina Nucleare, Università e Spedali Civili, Brescia, Italy

mMontefiore Medical Center, Yeshiva University, New York, New York

nDepartment of Radiology, Emory University Hospital, Emory University School of Medicine, Atlanta, Georgia, USA

Correspondence to Ernest V. Garcia, PhD, Department of Radiology, Emory University Hospital, Emory University School of Medicine, 1364 Clifton Rd., Atlanta, Georgia 30322, USA Tel: +1 404 712 7641; fax: +1 404 727 3488; e-mail:

This is an open-access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be changed in any way or used commercially.

Received February 7, 2014

Accepted March 25, 2014

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins