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Clinical significance of diffusely increased splenic uptake on FDG-PET

Liu, Yiyan

Nuclear Medicine Communications: October 2009 - Volume 30 - Issue 10 - p 763-769
doi: 10.1097/MNM.0b013e32832fa254
Review Article

Diffusely increased uptake is more commonly observed than focal uptake in the spleen on a whole-body [18F] fluorodeoxyglucose-positron emission tomography/computed tomography. The significance of diffusely increased splenic uptake varies in different clinical settings. On a pre-therapeutic scan for lymphoma, splenic uptake, greater than hepatic uptake, is a relative reliable indication of lymphomatous involvement of the spleen, unless the patient has a history of recent cytokine administration. In HIV infection, increased splenic uptake is usually noted in the early stage of the disease, which could reflect massive stimulation of B-cells in the spleen by nonreplicating antigenic material. Diffusely increased splenic uptake may also be present in sarcoidosis, malaria, and many inflammatory or hematopoietic diseases. Therapeutic-related reactive splenic uptake concurrent with bone marrow uptake is often secondary to administration of granulocyte colony-stimulating factor for myelosuppression or high-dose interferon-α-2b adjuvant therapy for melanoma.

Nuclear Medicine Service, Department of Radiology, University Hospital, UMDNJ, Newark, New Jersey, USA

Correspondence to Yiyan Liu, MD, PhD, Nuclear Medicine, University Hospital, H-141, 150 Bergen Street, Newark, NJ 07103, USA

Tel: +1 973 972 6022; fax: +1 973 972 6954; e-mail:

Received 27 March 2009 Accepted 15 June 2009

© 2009 Lippincott Williams & Wilkins, Inc.