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Prospective evaluation of the negative predictive value of V/Q SPECT using 99mTc-Technegas

Leblanc, Michel; Leveillée, Félix; Turcotte, Eric

Nuclear Medicine Communications: August 2007 - Volume 28 - Issue 8 - p 667-672
doi: 10.1097/MNM.0b013e32827a8e99

Objective To verify the negative predictive value of pulmonary ventilation/perfusion scintigraphy with single photon emission computed tomography (V/Q SPECT) in ruling out pulmonary thromboembolism.

Methods V/Q SPECT using 99mTc-Technegas was performed on 584 patients to rule out pulmonary thromboembolism between October 2004 and July 2005. Pulmonary thromboembolism was defined as any clear-cut vascular mismatch, regardless of size. Indeterminate scans were defined as cases having matching vascular type defects with a corresponding X-ray abnormality, or cases with equivocal mismatches. Other patterns were considered negative for pulmonary thromboembolism. Outcome data was gathered >3 months after the scan. Absence of pulmonary thromboembolism was defined as any patient still alive at least 3 months after the scan, with no anticoagulation treatment and no proof of pulmonary thromboembolism by other techniques, either at the time of the scan or during follow-up, or death by other causes.

Results One hundred and eight patients (19%) had a positive pulmonary thromboembolism reading, 18 (3%) an indeterminate study, and 458 (78%) patients had a negative reading for pulmonary thromboembolism. There were 189 patients with an abnormal chest X-ray. The mean follow-up time was 165 days. Of the 458 patients classified as negative for pulmonary thromboembolism, patients receiving chronic anticoagulation for other causes were excluded from follow-up (n=53), which left 405 patients for final analysis. There were no pulmonary thromboembolism-related deaths in the negative group. Six patients were identified as false negatives. The negative predictive value is estimated at 98.5%.

Conclusion SPECT pulmonary scintigraphy using 99mTc-Technegas demonstrates a high negative predictive value and a low indeterminate rate.

Department of Nuclear Medicine and Radiobiology, Centre Hospitalier Universitaire de Sherbrooke, Quebec, Canada

Correspondence to Dr Michel Leblanc, Department of Nuclear Medicine, Centre Hospitalier régional De Trois-Rivières, 1991 boul. du Carmel, Trois-Rivières, Qc, Canada G8Z 3R9

Tel: +1 819 697 3333 (ext: 69854); fax: +1 819 378 9814;


Received 28 March 2007 Revised 15 May 2007 Accepted 18 May 2007

© 2007 Lippincott Williams & Wilkins, Inc.