Clinical Nuclear Medicine

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This month's editor's favorite is Zheng and colleague's “68Ga-FAPI Versus 18F-FDG PET/CT in Evaluating Newly Diagnosed Breast Cancer Patients- A Head-to-Head Comparative Study."​

This study compared the performance of 68Ga-FAPI and 18F-FDG PET/CT within one week in 34 women with newly diagnosed breast cancer. The imaging characteristics of primary lesions, diagnostic efficiency of lymph node metastasis (LNM), and accuracy of N stage evaluation were compared between the two PET/CTs.

68Ga-FAPI showed higher SUVmax (11.06 ± 5.48 vs 8.33 ± 6.07, P = 0.02) and tumor-to-background ratio (15.32 ± 10.33 vs 8.25 ± 5.51, P < 0.001) than 18F-FDG in primary tumors. 68Ga-FAPI SUVmax was positively correlated with the pathological grade of the primary lesions and the final stage of the patients ( P < 0.001). The specificity and accuracy of 68Ga-FAPI was higher than that of 18F-FDG in the diagnosis of LNMs on patient-based and lesion-based analysis ( P < 0.001). The accuracy for the evaluation of N stage and N0 axillar status was 91.2% (31/34) and 85.7% (12/14) for 68Ga-FAPI, and 73.5% (25/34) and 42.9% (6/14) for 18F-FDG, respectively.

The authors concluded that 68Ga-FAPI SUVmax was positively correlated with the pathological grade of the primary lesions and the final stage of the patients. 68Ga-FAPI PET/CT has higher accuracy than 18F-FDG in the evaluation of N stage, especially N0 axillary status, which is helpful to improve the treatment strategy for breast cancer patients.

Current Issue

Somatostatin Receptor-Directed PET/CT for Therapeutic Decision-Making and Disease Control in Patients Affected With Small Cell Lung Cancer

Serfling, Sebastian E.; Hartrampf, Philipp E.; Zhi, Yingjun; More

Clinical Nuclear Medicine. 48(4):309-314, April 2023.

Impact of 18F-Fluciclovine PET/CT Findings on Failure-Free Survival in Biochemical Recurrence of Prostate Cancer Following Salvage Radiation Therapy

Lawal, Ismaheel O.; Marcus, Charles; Schuster, David M.; More

Clinical Nuclear Medicine. 48(4):e153-e159, April 2023.

68Ga-DOTA.SA.FAPI as a Potential, Noninvasive Diagnostic Probe for Recurrent and Metastatic Adrenocortical Carcinoma: A Head-to-Head Comparison With 18F-FDG

Chopra, Sejal; Walia, Rama; Mathur, Yamini; More

Clinical Nuclear Medicine. 48(4):e173-e175, April 2023.

A Discordant Pattern of Uptake on 68Ga-PSMA PET/CT Versus 18F-Fluciclovine PET/CT in Radiation-Induced Hepatitis: Implications for Early Postradiotherapy Imaging-Based Response Assessment

Adediran, Omotayo A.; Lawal, Ismaheel O.; Muzahir, Saima; More

Clinical Nuclear Medicine. 48(4):e202-e203, April 2023.