Clinical Nuclear Medicine

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This month's editor's favorite is Kunikowska and colleagues' “68Ga–Prostate-Specific Membrane Antigen PET/CT in Ovarian Tumors Potential to Differentiate Benign and Malignant Tumors Before Surgery: A Preliminary Report". They aim their pilot study of 8 women with mean age of 56.0 ± 16.2 years with suspected ovarian cancer to evaluate the feasibility of using 68Ga-PSMA-11 PET/CT for the detection of ovarian neoplasm before surgical treatment. All participants underwent transvaginal ultrasound followed by CT scan of the chest and abdomen as qualification for surgery. Within a 1-week interval, PET/CT was performed, 60 minutes after injection of 2 MBq/kg 68Ga-PSMA-11.

68Ga-PSMA-11 PET/CT was positive in 3 cases (37.5%), whereas histological examination confirmed 2 serous ovarian cancer cases and 1 ovarian borderline tumor. The SUVmax in the serous ovarian cancer was 8.7 and 4.1, and in the borderline ovarian tumor, it was 13.8. No correlation was found between antigen CA-125 level and 68Ga-PSMA expression. Range of tumor SUVmax was not correlated with stage of disease.

68Ga-PSMA-11 PET/CT was negative in the remaining 62.5% (5/8), and histopathology confirmed benign pelvic tumor.

The authors concluded that their initial 8 patient pilot experience supports the potential to use 68Ga-PSMA-11 in suspected ovarian cancer to differentiate malignant and benign tumors before surgery.

Current Issue

Head-to-Head Comparison Between Rabbit Sign and EANM/SNMMI Criteria for the 18F-DOPA Visual Assessment of Parkinsonian Syndromes in PET/MRI: A Multiple Expert-Based and Blinded Controlled Study

Goldfarb, Lucas; Iep, Alex; Chawki, Mohammad Bilal; More

Clinical Nuclear Medicine. 48(2):112-118, February 2023.

First Clinical Experience With [68Ga]Ga-FAPI-46-PET/CT Versus [18F]F-FDG PET/CT for Nodal Staging in Cervical Cancer

Wegen, Simone; Roth, Katrin Sabine; Weindler, Jasmin; More

Clinical Nuclear Medicine. 48(2):150-155, February 2023.

The Concept of Strength Through Synergy Applied to the Search of Powerful Prognostic Biomarkers in Gastroesophageal Cancer: An Example Based on Combining Clinicopathological Parameters, Imaging-Derived Sarcopenia Measurements, and Radiomic Features

Delgado Bolton, Roberto C.; Calapaquí Terán, Adriana K.; Fanti, Stefano; More

Clinical Nuclear Medicine. 48(2):156-157, February 2023.