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In this issue, Hou and colleagues present “68Ga-NOTA-EvansBlue TOF PET/MR Lymphoscintigraphy Evaluation of the Severity of Lower LimbLymphedema”.

This study uses 68Ga-NOTAEvans Blue (NEB) time-of-flight (TOF) PET/MR for the visual and parametric evaluation of lower limb lymphedema in thirteen patients with unilateral lower limb lymphedema. The patients were divided into 3 clinical severity groups: minimal (4 patients), moderate (5 patients), and severe (4 patients). The ratio of the SUV of superficial lymphatic vessel (SLV) versus SUV of deep lymphatic vessel (DVL), (SUVslv/dlv) was used as a measure of lymphedema severity.

There was a significant difference in the SUVslv between the affected limbs and normal limbs in all participants (affected limbs: 0.57 ± 0.32, normal limbs: 1.86 ± 1.43; P < 0.05), which was not found in the SUVdlv, (affected limbs: 0.64 ± 0.39, normal limbs: 0.63 ± 0.31; P > 0.1). The SUVslv/dlv of the affected limbs showed statistical differences within the 3 groups (P < 0.05) (minimal group: 1.91 ± 0.45; moderate group: 0.84 ± 0.16; severe group: 0.42 ± 0.11).

There was a negative correlation between SUVslv/dlv and the severity of lymphedema (r = −0.899; P < 0.01).

Authors concluded that 68Ga-NEB TOF PET/MR lymphoscintigraphy can provide anatomical and functional information of lymphatic vessels to guide surgery plans. SUVslv/dlv was well correlated with clinical lymphedema severity and might be potential in evaluating bilateral lower limb lymphedema.

68Ga- NEB TOF PET/MR lymphoscintigraphy may be useful for confirming lymphedema and planning lympho-venous surgery in selected patients.

Current Issue

Comparison of L-Methyl-11C-Methionine PET With Magnetic Resonance Spectroscopy in Detecting Newly Diagnosed Glioma

Kebir, Sied; Lazaridis, Lazaros; Weber, Manuel; More

Clinical Nuclear Medicine. 44(6):e375-e381, June 2019.