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This month's editors favorite is "The Use of Random Forests to Identify Brain Regions on Amyloid and FDG PET Associated With MoCA Score".  Zukotynski and colleagues applied random forests (RFs) to identify ROIs on 18F-florbetapir and 18F-FDG PET associated with Montreal Cognitive Assessment (MoCA) scores prospectively in 57 multicenter participants with white matter disease presenting with either transient ischemic attack or lacunar stroke or mild cognitive impairment or early Alzheimer disease. Scans were processed using the MINC toolkit to generate SUVratios, normalized to cerebellar gray matter for 18F-florbetapir PET or pons for 18F-FDG PET. SUV ratio data and MoCA scores were used for supervised training of RFs programmed in MATLAB.

18F-Florbetapir PETs were randomly divided into 40 training and 17 testing scans with 100 RFs of 1000 trees, constructed from a random subset of 16 training scans and 20 ROIs, identified ROIs associated with MoCA score: right posterior cingulate gyrus, right anterior cingulate gyrus, left precuneus, left posterior cingulate gyrus, and right precuneus. Amyloid increased with decreasing MoCA score.

18F-FDG PETs were randomly divided into 40 training and 15 testing scans with 100 RFs of 1000 trees, each tree constructed from a random subset of 16 training scans and 20 ROIs, identified ROIs associated with MoCA score: left fusiform gyrus, left precuneus, left posterior cingulate gyrus, right precuneus, and left middle orbitofrontal gyrus. 18F-FDG decreased with decreasing MoCA score.

Authors concluded that random forests help pinpoint clinically relevant ROIs associated with MoCA score. Amyloid increased and 18F-FDG decreased with decreasing MoCA score, most significantly in the posterior cingulate gyrus (p = 0.006).



Current Issue


The Use of Random Forests to Identify Brain Regions on Amyloid and FDG PET Associated With MoCA Score

Zukotynski, Katherine; Gaudet, Vincent; Kuo, Phillip H.; More

Clinical Nuclear Medicine. 45(6):427-433, June 2020.





Differences in 18F-FDG Uptake and Expression of Glucose Transporter Between 2 Distinct Subtypes of Mass-Forming Intrahepatic Cholangiocarcinomas

Kozaka, Kazuto; Kobayashi, Satoshi; Takamura, Hiroyuki; More

Clinical Nuclear Medicine. 45(6):e267-e273, June 2020.

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