Editor's Favorite: Nakanishi N and colleagues article "Impact of Patient Age and Histological Type on Radioactive Iodine Avidity of Recurrent Lesions of Differentiated Thyroid Carcinoma"​ retrospectively correlates the impact of age and histological type on the RAI avidity of recurrent lesions of DTC in 258 patients; 189 with classic papillary thyroid carcinoma [cPTC], 8 with follicular variant of papillary thyroid carcinoma, and 61 with follicular thyroid carcinoma.

They demonstrated a significant inverse correlation with age (<55 years, 36.2%; ≥55 years, 3%; p < 0.001) and RAI-avid cPTC lung metastases. Contrarily, RAI avidity for follicular thyroid carcinoma metastases was not influenced by age.  Authors argue for earlier consideration of molecular-targeted drugs in patients with older than 55 with classic papillary thyroid carcinoma, especially if there is no visual evidence for radioiodine avid metastases.​

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