In this issue, Hou and colleagues present “68Ga-NOTA-EvansBlue TOF PET/MR Lymphoscintigraphy Evaluation of the Severity of Lower LimbLymphedema”.
This study uses 68Ga-NOTAEvans Blue (NEB) time-of-flight
(TOF) PET/MR for the visual and parametric evaluation of lower limb lymphedema
in thirteen patients with unilateral lower limb lymphedema. The patients were
divided into 3 clinical severity groups: minimal (4 patients), moderate (5
patients), and severe (4 patients). The ratio of the SUV of superficial
lymphatic vessel (SLV) versus SUV of deep lymphatic vessel (DVL), (SUVslv/dlv) was
used as a measure of lymphedema severity.
There was a significant difference in the SUVslv between the
affected limbs and normal limbs in all participants (affected limbs: 0.57 ±
0.32, normal limbs: 1.86 ± 1.43; P < 0.05), which was not found in the
SUVdlv, (affected limbs: 0.64 ± 0.39, normal limbs: 0.63 ± 0.31; P > 0.1).
The SUVslv/dlv of the affected limbs showed statistical differences within the 3
groups (P < 0.05) (minimal group: 1.91 ± 0.45; moderate group: 0.84 ± 0.16;
severe group: 0.42 ± 0.11).
There was a negative correlation between SUVslv/dlv and the
severity of lymphedema (r = −0.899; P < 0.01).
Authors concluded that 68Ga-NEB TOF PET/MR
lymphoscintigraphy can provide anatomical and functional information of
lymphatic vessels to guide surgery plans. SUVslv/dlv was well correlated with
clinical lymphedema severity and might be potential in evaluating bilateral
lower limb lymphedema.
68Ga- NEB TOF PET/MR lymphoscintigraphy may be useful for
confirming lymphedema and planning lympho-venous surgery in selected patients.