Clinical Nuclear Medicine

Detailed Assessment of 18 F-THK5351 Distribution Pattern in the Midbrain: Comparison With Progressive Supranuclear Palsy and Corticobasal Syndrome
A Head-to-Head Comparison of 68 Ga-LNC1007 and 2- 18 F-FDG/ 68 Ga-FAPI-02 PET/CT in Patients With Various Cancers
Transformed Giant Congenital Melanocytic Nevus on 18 F-FDG PET/CT
FDG-Avid Malakoplakia of the Ureter Mimicking Malignancy
Noninvasive Verification of a Very Small Intraocular Prostate Carcinoma Metastasis by 68 Ga-PSMA-11 PET/CT
Asthma as an Inflammatory Reason of Tracheobronchial PSMA Uptake

Editor's Note

This month's Editor's favorite is Zang and colleagues: “A Head-to-Head Comparison of 68Ga-LNC1007 and 18F-FDG/68Ga-FAPI-02 PET/CT in Patients With Various Cancers". This head-to-head comparison study using 68Ga-LNC1007, to detect the primary and metastatic lesions in patients with various types of cancer, and to compare the results with those of 18F-FDG PET/CT and 68Ga-FAPI-02 PET/CT.

Sixty-one patients with 10 different kinds of cancers were enrolled. Fifty patients underwent paired 68Ga- LNC1007 and 18F-FDG PET/CT, and the other 11 patients underwent paired 68Ga-LNC1007 and 68Ga-FAPI-02 PET/CT. The final diagnosis was based on histopathological results and diagnostic radiology. Immunohistochemistry for FAP and integrin αvβ3 was performed in 24 primary tumors.

68Ga-LNC1007 PET/CT detected all 55 primary tumors, whereas 18F-FDG PET/CT was visually positive for 45 primary tumors (P = 0.002). Subgroup analysis showed that 68Ga-LNC1007 PET/CT was superior to 2-18F-FDG PET/CT in diagnosing renal cell carcinomas and hepatocellular carcinomas. For metastatic tumors, 68Ga-LNC1007 PET/CT revealed more PET-positive lesions and higher SUVmax for skeletal metastases and peritoneal metastases compared with 18F-FDG. The SUVmax and tumor-to-background ratio of primary tumors on 68Ga-LNC1007 PET/CT were much higher than those on 68Ga-FAPI-02 PET/CT, the same was also observed for metastatic tumors. Immunohistochemical results showed that the SUVmean quantified from 68Ga-LNC1007 PET was correlated with FAP expression level (r = 0.564, P = 0.005). The results are most effectively demonstrated in Figure 1.

The authors concluded that 68Ga-LNC1007 is a promising new diagnostic PET tracer for imaging of various kinds of malignant lesions. It may be a better alternative to 18F-FDG for diagnosing renal cell carcinoma, hepatocellular carcinoma, skeletal metastases, and peritoneal metastases.

Current Issue

Original Articles

Detailed Assessment of ¹⁸F-THK5351 Distribution Pattern in the Midbrain: Comparison With Progressive Supranuclear Palsy and Corticobasal Syndrome

Ishibashi, Kenji; Kurihara, Masanori; Ihara, Ryoko; More

Clinical Nuclear Medicine. 48(10):841-846, October 2023.

Open
SDC

Biodistribution and Internal Dosimetry of ⁶⁸Ga-DOTA-IBA PET Imaging for Patients With Bone Metastases

Yang, Jian; Deng, Jia; Fan, Dongmei; More

Clinical Nuclear Medicine. 48(10):847-852, October 2023.

Buy

Evaluation of LAT1 Expression in Patients With Lung Cancer and Mediastinal Tumors: ¹⁸F-FBPA PET Study With Immunohistological Comparison

Watabe, Tadashi; Ose, Naoko; Naka, Sadahiro; More

Clinical Nuclear Medicine. 48(10):853-860, October 2023.

Open

A Head-to-Head Comparison of ⁶⁸Ga-LNC1007 and 2-¹⁸F-FDG/⁶⁸Ga-FAPI-02 PET/CT in Patients With Various Cancers

Zang, Jie; Lin, Rong; Wen, Xuejun; More

Clinical Nuclear Medicine. 48(10):861-868, October 2023.

Free

Topical ¹⁸⁸Re Ionizing Radiation Therapy Exerts High Efficacy in Curing Nonmelanoma Skin Cancer

Tietze, Julia K.; Heuschkel, Martin; Krönert, Maila I. C.; More

Clinical Nuclear Medicine. 48(10):869-876, October 2023.

Buy
SDC

Impact of ¹⁸F-DCFPyL PET/MRI in Selecting Men With Low-/Intermediate-Risk Prostate Cancer for Focal Ablative Therapies

Basso Dias, Adriano; Ghai, Sangeet; Ortega, Claudia; More

Clinical Nuclear Medicine. 48(10):e462-e467, October 2023.

Buy
SDC

Interesting Images

Transformed Giant Congenital Melanocytic Nevus on ¹⁸F-FDG PET/CT

Feng, Chengtao; Li, Ke; Wang, Chun; More

Clinical Nuclear Medicine. 48(10):877-878, October 2023.

Buy

Unexpected Axillary Lymph Node Uptake During Lower-Limb Lymphoscintigraphy in a Case With Vulvar Lymphangioma Circumscriptum

Soydas-Turan, Basak; Tuncel, Murat

Clinical Nuclear Medicine. 48(10):879-880, October 2023.

Buy

Striatal Hyperperfusion Observed in Dual-Phase ¹⁸F-FP-CIT PET Imaging of Hyperglycemic Chorea

Kim, Yoon Seob; Park, Don Gueu; Shin, In Ja; More

Clinical Nuclear Medicine. 48(10):881-882, October 2023.

Buy

Serial ⁶⁸Ga-FAPI PET/CT After Treatment of Immunoglobulin G4-Related Pancreatitis and Retroperitoneal Fibrosis

Cho, Eunae; Park, Chang Hwan; Kim, Jahae; More

Clinical Nuclear Medicine. 48(10):883-887, October 2023.

Buy

Divergent Findings in the Diagnosis of ATTR-CM Using Common Cardiac Diagnostics and ^99mTc-DPD Scintigraphy

Kunte, Sophie C.; Schwarting, Stéphanie K.; Holzgreve, Adrien; More

Clinical Nuclear Medicine. 48(10):888-889, October 2023.

Buy

¹⁸F-FDG PET/CT Reveals Localized Inflammation in Lupus Enteritis

Sakuma, Shota; Abe, Yoshiyuki; Takeuchi, Motoki; More

Clinical Nuclear Medicine. 48(10):890-893, October 2023.

Buy

Langerhans Cell Histiocytosis Showed Intense Uptake of ⁶⁸Ga-FAPI

Pan, Qingqing; Zhang, Hongzhe; Cao, Xinxin; More

Clinical Nuclear Medicine. 48(10):894-895, October 2023.

Buy

Renal Interstitial Fibrosis Detected on ¹⁸F-AlF-NOTA-FAPI-04 PET/CT in a Patient With Multiple Myeloma

Wang, Hao; Deng, Yujiao; He, Limeng; More

Clinical Nuclear Medicine. 48(10):896-898, October 2023.

Buy

Comparison of ¹⁸F-FDG and ⁶⁸Ga-FAPI PET/CT in a Rare Renal Leiomyoma

Liu, Yanggang; Zhang, Shumao; Lan, Lianjun; More

Clinical Nuclear Medicine. 48(10):899-901, October 2023.

Buy

FDG PET/CT in Follicular Dendritic Cell Sarcoma of the Jejunum With Hepatic Metastasis

Ji, Xia; Dong, Aisheng; Wang, Yang

Clinical Nuclear Medicine. 48(10):902-904, October 2023.

Buy

Primary Angiosarcoma of Lumbar Pedicle and Transverse Process Revealed by FDG PET/CT

Yang, Pei; Xiao, Liu; Li, Lin

Clinical Nuclear Medicine. 48(10):905-906, October 2023.

Buy

FDG-Avid Malakoplakia of the Ureter Mimicking Malignancy

Zhao, Qian; Dong, Aisheng; Zuo, Changjing; More

Clinical Nuclear Medicine. 48(10):907-909, October 2023.

Buy

A Case of Primary Esophageal Sarcomatoid Carcinoma Detected by ¹⁸F-FDG PET/CT

Chen, Tao; Li, Wenfei; Fan, Jianzhong

Clinical Nuclear Medicine. 48(10):910-912, October 2023.

Buy

⁶⁸Ga-PSMA-11 PET/CT in a Case of Isolated Parietal Peritoneal Metastasis From Prostate Adenocarcinoma

Zhao, Qian; Dong, Aisheng; Zuo, Changjing

Clinical Nuclear Medicine. 48(10):913-914, October 2023.

Buy

Noninvasive Verification of a Very Small Intraocular Prostate Carcinoma Metastasis by ⁶⁸Ga-PSMA-11 PET/CT

Ndum, Ferdinand; Seifert, Philipp; Freesmeyer, Martin; More

Clinical Nuclear Medicine. 48(10):915-916, October 2023.

Buy

Enlarging ¹⁸F-FDG–Avid Solitary Pulmonary Nodule: A Distinctly Unusual Presentation of Cytomegalovirus Infection in a Patient Receiving Chemotherapy

Zamora, Edgar; Edema, Ukuemi; Zuckier, Lionel S.

Clinical Nuclear Medicine. 48(10):917-918, October 2023.

Buy

¹⁸F-FES Uptake in Radiation Pneumonitis

Mahalik, Aparna; Chaudhary, Beena; Kumar, Rakesh; More

Clinical Nuclear Medicine. 48(10):e468-e469, October 2023.

Buy

Excellent Response to Full-Dose ¹⁷⁷Lu-PSMA-617 RLT in Metastatic Castration-Resistant Prostate Cancer With Transplant Kidney: A Step Ahead

Mahdi, Raza Abbas; Aggarwal, Piyush; Kumar, Suraj; More

Clinical Nuclear Medicine. 48(10):e470-e471, October 2023.

Buy

¹⁸F-FDG PET/CT to Spare Malignancy in a Rare Case of Lung Endometriosis

Padilla Bermejo, Amanda; García Zoghby, Laura; Pena Pardo, Francisco José; More

Clinical Nuclear Medicine. 48(10):e472-e473, October 2023.

Buy

Increased ¹⁸F-FAPI Uptake in Radiation-Induced Liver Injury

Zhang, Jing; Jiang, Shuqin; Zhang, Rusen; More

Clinical Nuclear Medicine. 48(10):e474-e476, October 2023.

Buy

Visualization of Thromboinflammation by ¹⁸F-DPA-714 PET in a Stroke Patient

Lin, Qianqian; Wang, Youliang; Zhao, Wenlong; More

Clinical Nuclear Medicine. 48(10):e477-e479, October 2023.

Buy

⁶⁸Ga-DOTA-FAPI-04 Imaging of Bilateral Phyllodes Tumor

Alçın, Göksel; Arslan, Esra; Baykara Ulusan, Melis; More

Clinical Nuclear Medicine. 48(10):e480-e482, October 2023.

Buy

Use of ¹⁸F-PSMA PET to Distinguish Cerebral Radiation Necrosis From Tumor Recurrence

Rayamajhi, Sampanna Jung; Ponisio, Maria Rosana; Siegel, Barry

Clinical Nuclear Medicine. 48(10):e483-e484, October 2023.

Buy

Bone Lipogranuloma Mimicking Metastatic Disease on ¹⁸F-FDG PET/CT

Kesim, Selin; Dede, Fuat; Cesmecioglu, Emine; More

Clinical Nuclear Medicine. 48(10):e485-e486, October 2023.

Buy

An Enigmatic Case of Skeletal Fluorosis: Inhalant-Induced Toxicity

DeMarco, Kara M.; Major, Joshua W.; Young, Colin R.; More

Clinical Nuclear Medicine. 48(10):e487-e488, October 2023.

Buy

Clinical Application of ¹⁸F-THK5351 PET to Identify Inflammatory Lesions Through Imaging Astrogliosis in a Case of Cytomegalovirus Ventriculoencephalitis

Hatano, Keiko; Ishibashi, Kenji; Yamada, Kazuki; More

Clinical Nuclear Medicine. 48(10):e489-e490, October 2023.

Buy

¹⁷⁷Lu-PSMA Treatment Monitoring Through Serial Fast Whole-Body Tomoscintigraphies Recorded With a Latest-Generation CZT-Camera

Boursier, Caroline; Olivier, Pierre; Claudin, Marine; More

Clinical Nuclear Medicine. 48(10):e491-e493, October 2023.

Buy
SDC

Asthma as an Inflammatory Reason of Tracheobronchial PSMA Uptake

Bronte Viedma, Ángela; Bastidas Tamayo, Juan Fernando; Rosales Castillo, Juan José; More

Clinical Nuclear Medicine. 48(10):e494-e495, October 2023.

Buy

¹⁸F-FDG PET/CT in a Patient With Epididymo-Testicular Malacoplakia

Zhao, Xulong; Long, Zaiying; Yu, Liming; More

Clinical Nuclear Medicine. 48(10):e496-e499, October 2023.

Buy

Intravenous Pyogenic Granuloma in the Inguinal Canal Mimicking Lymph Node Metastasis on PSMA PET/CT

Skyum, Sarah MD.; Anthonsen, Andrea K.; Salkus, Giedrius; More

Clinical Nuclear Medicine. 48(10):e500-e502, October 2023.

Buy

Right Adrenocortical Carcinoma Coexisting With Left Adrenal Sarcomatoid Carcinoma on FDG PET/CT

Chen, Haotian; Dai, Jiaona; Gao, Fabao; More

Clinical Nuclear Medicine. 48(10):e503-e505, October 2023.

Buy

Prostate Adenocarcinoma Metastasis to the Rectal Submucosa and Mesorectal Lymph Node on ¹⁸F-PSMA PET/CT

Segal, Eric; Dababo, Nour; Bhalla, Deepali; More

Clinical Nuclear Medicine. 48(10):e506-e508, October 2023.

Buy

From the American College of Nuclear Medicine

Quality and Safety in Healthcare, Part XCIII: Design for Six Sigma and Lean Six Sigma

Harolds, Jay A.

Clinical Nuclear Medicine. 48(10):919-921, October 2023.

Buy
SDC

Image Viewer

Journal Info

October 2023, Vol. 48, Issue 10

Editor-in-Chief:
Patrick M. Colletti, M.D.

ISSN: 0363-9762

Online ISSN: 1536-0229

Frequency: 12 issues / year

Ranking: Radiology, Nuclear Medicine, and Medical Imaging 4/135

Impact Factor: 10.6

Official Journal of the American College of Nuclear Medicine

ACNM is inviting international nuclear physicians, scientists, residents in training, nuclear pharmacists and industry to apply for full ACNM membership.

View articles from the ACNM

COVID-19 Guidance and Articles

The American College of Nuclear Medicine Guidance on Operating Procedures for a Nuclear Medicine Facility During COVID-19 Pandemic.

Incidental CT Findings Suspicious for Covid-19 Associated Pneumonia on Nuclear Medicine Exams: Recognition and Management Plan.

¹⁸F-FDG PET/CT and Serial Chest CT Findings in a COVID-19 Patient With Dynamic Clinical Characteristics in Different Period.

A Message from the ACNM President

It is the greatest honor of my professional life to lead the American College of Nuclear Medicine in 2021. Thank you for placing your trust in me. At my inauguration during the 2021 Annual Meeting, I pledged to lead by example and to listen carefully to every member's thoughts on how to improve our organization, how together we could enhance ACNM services to members and patients, as well as how to best contribute to the public health and public good.

Continue reading here.

80th Anniversary of the First Radiodine Treatment

80th anniversary of the First Radiodine Treatment.png

On April 1st, we commemorated the 80^th Anniversary of the first therapeutic use of radioactive sodium iodide (I-130) given to a young woman with Graves' Disease by Dr. Saul Hertz in 1941. The title banner is a clip from the table made by the legendary physician who conceived the idea, studied iodine kinetics on the animal model, and finally took it to the clinic by literally running a vial with radioactive iodine (RAI) from the cyclotron facility at the Massachusetts Institute of Technology (MIT) to the Thyroid Unit at the Massachusetts General Hospital (MGH) where he was the Clinical Director. The first patient, a young woman suffering from Graves' disease, was waiting for him to bring the novel radioactive medicine for her experimental treatment! Read more here.

Most Popular

Featured Jobs