Breast-conserving surgery with intraoperative assessment of lesion margins and sentinel lymph node biopsy has become the preferred method of treatment for selected patients with early infiltrating breast cancer. A high-energy gamma probe, designed according to a novel concept of electronic collimation and variable energy window, was used in a patient with nonpalpable infiltrating breast cancer to perform simultaneous intraoperative identification of lesion margins (based on the detection of the high-energy gamma rays originated from annihilation following preoperative administration of F-18 FDG) and radioguided sentinel node biopsy (based on the single-photon agent Tc-99m-nanocolloid used for lymphoscintigraphy).
From the *Regional Center of Nuclear Medicine, University of Pisa Medical School, Pisa, Italy; and †Breast Unit, University Hospital of Pisa, Department of Oncology Transplants and Advanced Technologies in Medicine, University of Pisa, Italy.
Received for publication February 8, 2011; revision accepted March 3, 2010.
Conflicts of interest and sources of funding: none declared.
Reprints: Gianpiero Manca, MD, PhD, Regional Center of Nuclear Medicine, University Hospital of Pisa, Via Roma 67, I-56100 Pisa, Italy. E-mail: firstname.lastname@example.org.