Interesting ImagesIntense Uptake in Amyloidosis of the Seminal Vesicles on 68Ga-PSMA PET Mimicking Locally Advanced Prostate CancerStephens, Maximilian MBB, BSc; Kim, David Insoo MBBS, BSc; Shepherd, Benjamin MBBS, FRCPA; Gustafson, Sonja FRANZCR; Thomas, Paul BMed, FRACP Author Information From the *Department of Nuclear Medicine, Royal Brisbane and Women’s Hospital, Herston, Queensland; †School of Medicine, University of Queensland, Brisbane, Queensland; ‡Royal Brisbane and Women’s Hospital, Herston; §Department of Anatomical Pathology, Pathology Queensland, Princess Alexandra Hospital, Woolloongabba, Queensland; ∥Department of Medical Imaging, Royal Brisbane and Women’s Hospital, Herston, Queensland; and ¶Herston Imaging Research Facility, Brisbane, Queensland, Australia. Received for publication September 30, 2016; revision accepted October 2, 2016. Conflicts of interest and sources of funding: none declared. Correspondence to: Maximilian Stephens, MBB, BSc, Department of Nuclear Medicine, Royal Brisbane and Women’s Hospital, Butterfield St, Herston, Queensland, Australia, 4006. E-mail: [email protected]. Clinical Nuclear Medicine 42(2):p 147-148, February 2017. | DOI: 10.1097/RLU.0000000000001460 Buy Metrics Abstract We report a case of benign senile seminal vesicle amyloidosis demonstrating intense 68Ga–prostate-specific membrane antigen (PSMA) uptake on PET/CT. A 68-year-old man underwent staging PSMA PET/CT and MRI for biopsy-proven prostate adenocarcinoma. There was an intense focus of 68Ga-PSMA uptake in the primary malignancy, as well as symmetrical intense uptake in the seminal vesicles bilaterally that was reported as multifocal disease with local invasion. Final histology after radical prostatectomy showed amyloidosis of the seminal vesicles without any evidence of prostate cancer. Care should be taken in the interpretation of seminal vesicle PSMA uptake to avoid overstaging. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.