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18F-Fluoride Uptake in Soft Tissue Metastases of Medullary Thyroid Carcinoma as a Marker of Progressive Calcification

Duarte, Paulo Schiavom, MD, PhD*; Marin, José Flávio Gomes, MD*; Filho, George Barberio Coura, MD, PhD*; Sapienza, Marcelo Tatit, MD, PhD; Buchpiguel, Carlos Alberto, MD, PhD*†

doi: 10.1097/RLU.0000000000002259
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18F-fluoride (18F-NaF) uptake in soft tissue metastases of medullary thyroid carcinoma (MTC) has been reported. However, the evolution of these metastatic sites has rarely been assessed. We present a case of 18F-NaF uptake in multiple liver metastases of MTC initially without macroscopic calcification. The CT follow-up studies showed a progressive calcium deposition in the lesions. Therefore, this case suggests that the 18F-NaF uptake in MTC metastases could potentially be a marker of an ongoing calcification process instead of an inert deposit of calcium.

From the *Division of Nuclear Medicine, São Paulo Cancer Institute (ICESP); and

University of São Paulo Medical School (FMUSP), São Paulo, Brazil.

Received for publication June 26, 2018; revision accepted July 19, 2018.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Paulo Schiavom Duarte, MD, PhD, Division of Nuclear Medicine, São Paulo Cancer Institute (ICESP), Doutor Arnaldo Ave, N° 251, 4° SS, Cerqueira César, São Paulo, Brasil 01246-000. E-mail:

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