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Usefulness of F-18 FDG PET/CT in the Follow-up of POEMS Syndrome After Autologous Peripheral Blood Stem Cell Transplantation

Stefanelli, Antonella, MD*; Treglia, Giorgio, MD*; Leccisotti, Lucia, MD*; Laurenti, Luca, MD; Luigetti, Marco, MD; Sabatelli, Mario, MD; Giordano, Alessandro, MD*

doi: 10.1097/RLU.0b013e31823ea154
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We report a case of a patient with relapse of POEMS syndrome (peripheral neuropathy, organomegaly, endocrinopathy, monoclonal plasma proliferative disorder, skin changes) that occurred 6 years after an autologous peripheral blood stem cell transplantation. F-18 FDG PET/CT showed several hypermetabolic as well as nonhypermetabolic bone lesions. Based on these findings, the patient was referred for radiotherapy to the hypermetabolic bone lesions. After autologous peripheral blood stem cell transplantation, F-18 FDG PET/CT may play a pivotal role in detecting new bone lesions in patients with POEMS syndrome, which may be treated by a focalized radiotherapy and/or systemic therapy.

From the *Institute of Nuclear Medicine, Catholic University of the Sacred Heart, Rome, Italy; †Institute of Hematology, Catholic University of the Sacred Heart, Rome, Italy; and ‡Institute of Neurology, Catholic University of the Sacred Heart, Rome, Italy.

Received for publication March 18, 2011; revision accepted August 8, 2011.

A.S. and G.T. contributed equally to the work.

Conflicts of interest and sources of funding: none declared.

Reprints: Giorgio Treglia, MD, Institute of Nuclear Medicine and Positron Emission Tomography Centre, Department of Bioimages and Radiological Sciences, Catholic University of the Sacred Heart, Largo Gemelli, 8, 00168 Rome, Italy. E-mail:

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