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18F-Fluorocholine PET/CT Imaging of Brown Tumors in a Patient With Severe Primary Hyperparathyroidism

Zhang-Yin, Jules MD*; Gaujoux, Sébastien MD, PhD; Delbot, Thierry MD; Gauthé, Mathieu MD*; Talbot, Jean-Noël MD, PhD*

Clinical Nuclear Medicine: December 2019 - Volume 44 - Issue 12 - p 971–974
doi: 10.1097/RLU.0000000000002814
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Brown tumors are rare skeletal anomalies occurring in patients with hyperparathyroidism and exposing patients to pathological fractures. We report the case of a 26-year-old woman with severe primary hyperparathyroidism (calcemia, 2.9 mmol/L; parathyroid hormone, 59 pmol/L) who underwent 18F-fluorocholine (FCH) PET/CT before parathyroidectomy. FCH PET localized the hyperfunctioning parathyroid gland and showed multiple foci in correspondence with bone lytic lesions on CT. Those lesions were not visible on the 99mTc-MIBI dual-phase scintigraphy. The pathology of one of the FCH-positive bone lesions corresponded to a brown tumor related to hyperparathyroidism.

From the *Department of Nuclear Medicine, Hôpital Tenon & Sorbonne Université

Department of Pancreato-Biliary and Endocrine Surgery, Hopital Cochin & Sorbonne Paris Cité

Department of Nuclear Medicine, Hopital Cochin, Paris, France.

Received for publication May 4, 2019; revision accepted August 5, 2019.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Jules Zhang-Yin, MD, Médecine Nucléaire, Hôpital Tenon & Sorbonne Université, 4 Rue de la Chine, 75020, Paris, France. E-mail:

Online date: October 25, 2019

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.









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      18F-fluorocholine; PET/CT; 99mTc-MIBI; primary hyperparathyroidism; brown tumors

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