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Conjunctival MALT Lymphoma: Utility of FDG PET/CT for Diagnosis, Staging, and Evaluation of Treatment Response

Sallak, Asmaa MD*; Besson, Florent L. MD*; Pomoni, Anastasia MD*; Christinat, Alexandre MD; Adler, Marcel MD; Aegerter, Jean-Philippe MD; Nguyen, Christophe MD§; de Leval, Laurence MD, PhD; Frossard, Valérie MD; Prior, John O. PhD, MD*

doi: 10.1097/RLU.0000000000000356
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A 67-year-old woman was referred for staging of a mucosa-associated lymphoid tumor lymphoma involving the left conjunctiva. CT scan had shown paravertebral and pelvic masses, and a breast nodule. FDG PET/CT demonstrated moderately increased uptake in the left ocular conjunctiva and confirmed the paravertebral and pelvic masses and the breast nodule. Moreover, abnormal FDG uptake was shown in 2 breast nodules, the flank, the gluteus maximus, and the gastric cardia. The patient received 6 cycles of rituximab-bendamustine chemotherapy with a complete clinical and metabolic response at the 6-month follow-up PET/CT and remained relapse-free without visual acuity problem after a 36-month follow-up.

From the Departments of *Nuclear Medicine, †Oncology, and ‡Hematology, Lausanne University Hospital; §Jules Gonin Eye Hospital; ¶Department of Pathology, Lausanne University Hospital, Lausanne; and ∥Department of Oncology, Sion Hospital, Sion, Switzerland.

Received for publication July 8, 2013; revision accepted December 11, 2013.

Conflicts of interest and sources of funding: none declared.

Reprints: John O. Prior, PhD, MD, Department of Nuclear Medicine, Lausanne University Hospital, Rue du Bugnon 46, CH-1011 Lausanne, Switzerland. E-mail:

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.





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    18F; FDG; PET; ocular lymphoma; MALT; ocular adnexal MALT lymphoma; conjunctival MALT lymphoma

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