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Giant Anterior Mediastinal Parathyroid Adenoma

Li, Lianxi MD*†‡§; Chen, Libo MD; Yang, Yi MS; Han, Junfeng MD*†‡§; Wu, Songhua MD*†‡§; Bao, Yuqian MS*†‡§; Jia, Weiping MD, PhD*†‡§

doi: 10.1097/RLU.0b013e31825ae8b6
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A 57-year-old woman with type 2 diabetes was admitted to our hospital presenting with generalized bone pains, hypercalcemia, and elevated parathyroid hormone level. Enhanced CT scan demonstrated a large soft tissue mass in the right anterior mediastinum. 99mTc-MIBI scintigraphy revealed the focal accumulation of radiotracer uptake in the anterior mediastinum. 99mTc-MIBI SPECT/CT imaging also corroborated the same finding. The patient underwent surgery to have a giant ectopic parathyroid adenoma (7 × 4.5 × 1.5 cm) removed. The patient has been observed for 2 years, with normal parathyroid hormone and calcium levels.

From the *Shanghai Diabetes Institute; †Shanghai Clinical Center for Diabetes; ‡Shanghai Key Laboratory of Diabetes Mellitus; Departments of §Endocrinology and Metabolism, ¶Nuclear Medicine, and ∥Thoracic Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China.

Received for publication December 3, 2011; revision accepted March 27, 2012.

Lianxi Li, Libo Chen, and Yi Yang equally contributed to this work.

Conflicts of interest and sources of funding: This work was sponsored by grants from The National Natural Science Foundation of PR China (81170759). The authors have nothing to disclose.

Reprints: Weiping Jia, MD, PhD, Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, 600 Yishan Rd, Shanghai 200233, China. E-mail:





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                  hyperparathyroidism; ectopic parathyroid adenoma; mediastinum; scintigraphy; diabetes mellitus

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