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Elevated Iodine Uptake at Autogenous Bone Graft Harvest Sites

Yang, Jigang MD, PhD*†; Codreanu, Ion MD, PhD; Servaes, Sabah MD; Zhuang, Hongming MD, PhD

doi: 10.1097/RLU.0b013e31825b25a7
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A 16-year-old adolescent girl post total thyroidectomy for papillary thyroid carcinoma presented for postsurgical radioablative therapy. A whole-body 123I scintigraphy revealed not only expected activity in the thyroid bed but also asymmetric tracer distribution in the mandible and 2 foci of increased 123I accumulation in the distal left lower extremity. SPECT/CT images localized the activity to the donor sites of an autologous left fibular bone graft, harvested 8 years earlier to repair her mandible. Our case demonstrates that iodine accumulation can occur at the site of bone surgery many years after intervention and should be differentiated from iodine-avid metastases.

From the *Department of Nuclear Medicine, Beijing Friendship Hospital of Capital Medical University, Beijing, China; and †Department of Radiology, The Children’s Hospital of Philadelphia, Philadelphia, PA.

Received for publication March 19, 2012; and revision accepted March 27, 2012.

Conflicts of interest and sources of funding: Dr Yang was partially supported by the Natural Science Foundation of China (No. 81101069) and the Beijing Natural Science Foundation (No. 7112035). The other authors have nothing to declare.

Reprints: Hongming Zhuang, MD, PhD, Department of Radiology, The Children’s Hospital of Philadelphia, 34th St and Civic Center Blvd, Philadelphia, PA 19104. E-mail:





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                                          thyroid carcinoma; false-positive; bone graft

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