Interesting ImageDelayed Epiphyseal Closure in a Patient With β-Thalassemia Major Complicated by Hypogonadotrophic HypogonadismNguyen, Quyen H., BSc (med), MBBS, FRACP; Lin, Michael, BSc, MBBS, MRCP (UK), FRACP; Lin, Peter, MBBS, FRACP; Pocock, Nicholas, MBBS, MD, FRACPAuthor Information From the Liverpool Hospital, Sydney, NSW Australia. Received for publication September 20, 2006; accepted November 28, 2006. Reprints: Quyen H. Nguyen, Department of Nuclear Medicine, PET and Clinical Ultrasound, Liverpool Hospital, Elizabeth Drive, Liverpool, Sydney, NSW, Australia 2170. E-mail: email@example.com. Clinical Nuclear Medicine: November 2007 - Volume 32 - Issue 11 - p 874-877 doi: 10.1097/RLU.0b013e318156b9a6 Buy Metrics Abstract A 25-year-old man was referred for a bone scan to assess sacral pain on a background of β-thalassemia major complicated by severe anemia. He required repeated blood transfusions resulting in iron overload, which was treated with long-term iron chelation therapy. This case illustrates the potential skeletal manifestations of thalassemia and its treatment as demonstrated on bone scintigraphy, which include alterations in skeletal development and maturation, particularly delayed epiphyseal closure as well as complications of severe osteoporosis. Although the causes are multifactorial, pituitary iron deposition complicated by hypogonadotrophic hypogonadism should be considered as these patients may benefit from hormone replacement. © 2007 Lippincott Williams & Wilkins, Inc.