Interesting Image: PDF OnlyPrimary Central Nervous System Lymphoma Revealed by 68Ga-FAPI and 18F-FDG PET/CTZhang, Ying MD*; Cai, Jiawei MD†; Lin, Zefang MD*; Yao, Shaobo PhD*; Miao, Weibing MD, PhD*Author Information From the Departments of *Nuclear Medicine †Neurosurgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian Province, China. Received for publication October 11, 2020; revision accepted December 8, 2020. Conflicts of interest and sources of funding: This study was funded in part by the startup fund for scientific research of Fujian Medical University (2017XQ1078), The National Natural Science Foundation of China (81971651), Fujian Natural Science Foundation (2019J01454), and Tianjin Natural Science Foundation (18JCQNJC11600). None declared to all authors. Correspondence to: Weibing Miao, MD, PhD, Department of Nuclear Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China. E-mail: [email protected]; and Shaobo Yao, PhD, Department of Nuclear Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China. E-mail: [email protected]. Clinical Nuclear Medicine: January 28, 2021 - Volume Publish Ahead of Print - Issue - doi: 10.1097/RLU.0000000000003517 Buy PAP Metrics Abstract A 67-year-old woman presented with left limb weakness, facial paralysis, and unsteady gait for 1 month. Brain MRI detected a mass in the right frontal lobe with prominent peritumoral edema, suggesting a malignant brain tumor. In 18F-FDG PET/CT, the mass was very FDG avid, and 68Ga-FAPI PET/CT showed the mass had heterogeneously mild to moderate increased uptake of the tracer. Histopathological examination after surgical resection of the mass confirmed the diagnosis of diffuse large B-cell lymphoma. The current case indicated the existence of fibrosis in the lymphoma lesion to some extent. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.