From the ∗Department of Nuclear Medicine, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
†State Key Laboratory of Complex Severe and Rare Diseases, Beijing
‡PET Center, Nanfang Hospital, Southern Medical University, Guangzhou, China
§Department of Diagnostic Radiology, Yong Loo Lin School of Medicine and Faculty of Engineering
∥Clinical Imaging Research Centre, Centre for Translational Medicine
¶Nanomedicine Translational Research Program, NUS Center for Nanomedicine, Yong Loo Lin School of Medicine
∗∗Departments of Chemical and Biomolecular Engineering, and Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore, Singapore.
Received for publication February 1, 2023; revision accepted February 10, 2023.
Conflicts of interest and sources of funding: This study was supported by the Chinese Academy of Medical Science Innovation Fund for Medical Sciences (2021-I2M-1-016, 2022-I2M-2-002), Beijing Natural Science Foundation (M22035), National Natural Science Foundation of China (81871392), the National University of Singapore Start-up Grant (NUHSRO/2021/097/Startup/13; NUHSRO/2020/133/Startup/08), and National Medical Research Council Centre Grant Programme (CG21APR1005). The authors have no conflicts to report.
Trial registration treatment using 177Lu-DOTA-EB-TATE in patients with advanced neuroendocrine tumors (NCT03478358)
Y.J. and Q.L. contributed equally to this work.
Correspondence to: Xiaoyuan Chen, PhD, Department of Diagnostic Radiology, Yong Loo Lin School of Medicine and Faculty of Engineering, National University of Singapore, S9 Level 10, 4 Science Dr 2, Singapore 117544, Singapore. E-mail: [email protected]; Zhaohui Zhu, MD, Department of Nuclear Medicine, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan, Wangfujing St, Dongcheng District, Beijing 100730, China. E-mail: [email protected]; Jingjing Zhang, MD, Department of Diagnostic Radiology, Yong Loo Lin School of Medicine National University of Singapore, S9 Level 10, 4 Science Dr 2, Singapore 117544, Singapore. E-mail: [email protected].