Nodular Fasciitis

False Positive on 18F-Piflufolastat and 11C-Choline PET/CT

Abstract

PET/CT plays a crucial role in the management of prostate cancer with several emerging and established radiopharmaceuticals, including ¹⁸F-piflufolastat and ¹¹C-choline. These radiotracers are thought to be relatively specific to prostate cancer; however, uptake has also been demonstrated in other benign and malignant lesions. Nodular fasciitis is a rapidly growing benign soft tissue neoplasm that is typically self-limiting. Although a few case reports describe ⁶⁸Ga-PSMA uptake in nodular fasciitis, uptake of ¹¹C-choline and other PSMA-targeted PET probes, including ¹⁸F-piflufolastat, have not previously been reported. We present a novel case of nodular fasciitis demonstrating both ¹⁸F-piflufolastat and ¹¹C-choline avidity.