Interesting ImagesNormalization of Liver Physiological Uptake as a Response Marker to Treatment in Prostate Cancer Liver Metastases Appearing as Photopenic on Baseline 18F-Fluorocholine PET/CTFaudemer, Julie MD∗; Meriaux, Emeline MD†; Tillou, Xavier MD, PhD‡; Aide, Nicolas MD, PhD∗ Author Information From the ∗Nuclear Medicine Department, University Hospital †Oncology Department, François Baclesse Cancer Centre ‡Urology Department, University Hospital, Caen, France. Received for publication July 10, 2022; revision accepted August 25, 2022. Conflicts of interest and sources of funding: none declared. Correspondence to: Nicolas Aide, MD, PhD, Nuclear Medicine Department, University Hospital, Avenue Côte de Nacre, Caen, 14000, France. E-mail: [email protected]. Clinical Nuclear Medicine 48(2):p 182-183, February 2023. | DOI: 10.1097/RLU.0000000000004420 Buy Metrics Abstract In a 54-year-old patient referred for 18F-fluorocholine (FCH) baseline PET/CT before chemotherapy for biopsy-proven liver metastases, FCH PET/CT demonstrated multiple hypodense hepatic lesions with no FCH uptake and 2 positive bone metastases. FCH PET/CT performed after 6 cycles of docetaxel demonstrated a near normalization of the physiological uptake in the area of the sterilized liver metastases, which was confirmed by a drop in prostate-specific antigen and a complete metabolic response in the bone metastases. The present case demonstrates a new pattern of response defined by a reverse phenomenon from photopenic to normal uptake in responding liver metastases. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.