Interesting ImagesIncidental Finding of a Tongue Schwannoma Mimicking Local Recurrence of Squamous Cell Carcinoma on a Systematic Follow-up 18F-FDG PET/CTDzuko Kamga, Jacques MD∗; Leclere, Jean-Christophe MD†; Conan-Charlet, Virginie MD‡; Tissot, Valentin MD§; Abgral, Ronan MD, PhD∗,∥ Author Information From the Departments of ∗Nuclear Medicine †Oto-Rhino-Laryngology ‡Histopathology §Radiology, University Hospital of Brest ∥UMR INSERM 1304 GETBO, Brest, France. Received for publication June 7, 2022; revision accepted September 13, 2022. Conflicts of interest and sources of funding: none declared. Correspondence to: Jacques Dzuko Kamga, MD, Department of Nuclear Medicine, University Hospital of Brest, 2 Ave Foch, 29609 Brest Cedex, France. E-mail: [email protected]. Clinical Nuclear Medicine 48(2):p e92-e94, February 2023. | DOI: 10.1097/RLU.0000000000004461 Buy Metrics Abstract Schwannomas are usually benign, rare, and slow-growing nerve sheath tumor composed of Schwann cells. They develop in the head and neck area in approximately 25% to 40% of cases, of which 1% in the oral cavity, where the tongue remains the preferred site. Malignant transformation occurs in approximately 8% to 10% cases. We report a unique case of a histologically proven FDG-avid schwannoma of the left mobile portion of the tongue, showing an 18F-FDG avidity on PET/CT, which was a false-positive result for local recurrence in a patient followed for squamous cell carcinoma. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.